Adhesion G-protein coupled receptor F1 (G protein-coupled receptor 110) (G protein-coupled receptor KPG_012) (G protein-coupled receptor PGR19)
1_MKVGV 6_ LWLIS 11_ FFTFT 16_ DGHGG 21_ FLGKN 26_ DGIKT 31_ KKELI 36_ VNKKK 41_ HLGPV 46_ EEYQL 51_ LLQVT 56_ YRDSK 61_ EKRDL 66_ RNFLK 71_ LLKPP 76_ LLWSH 81_ GLIRI 86_ IRAKA 91_ TTDCN 96_ SLNGV 101_ LQCTC 106_ EDSYT 111_ WFPPS 116_ CLDPQ 121_ NCYLH 126_ TAGAL 131_ PSCEC 136_ HLNNL 141_ SQSVN 146_ FCERT 151_ KIWGT 156_ FKINE 161_ RFTND 166_ LLNSS 171_ SAIYS 176_ KYANG 181_ IEIQL 186_ KKAYE 191_ RIQGF 196_ ESVQV 201_ TQFRN 206_ GSIVA 211_ GYEVV 216_ GSSSA 221_ SELLS 226_ AIEHV 231_ AEKAK 236_ TALHK 241_ LFPLE 246_ DGSFR 251_ VFGKA 256_ QCNDI 261_ VFGFG 266_ SKDDE 271_ YTLPC 276_ SSGYR 281_ GNITA 286_ KCESS 291_ GWQVI 296_ RETCV 301_ LSLLE 306_ ELNKN 311_ FSMIV 316_ GNATE 321_ AAVSS 326_ FVQNL 331_ SVIIR 336_ QNPST 341_ TVGNL 346_ ASVVS 351_ ILSNI 356_ SSLSL 361_ ASHFR 366_ VSNST 371_ MEDVI 376_ SIADN 381_ ILNSA 386_ SVTNW 391_ TVLLR 396_ EEKYA 401_ SSRLL 406_ ETLEN 411_ ISTLV 416_ PPTAL 421_ PLNFS 426_ RKFID 431_ WKGIP 436_ VNKSQ 441_ LKRGY 446_ SYQIK 451_ MCPQN 456_ TSIPI 461_ RGRVL 466_ IGSDQ 471_ FQRSL 476_ PETII 481_ SMASL 486_ TLGNI 491_ LPVSK 496_ NGNAQ 501_ VNGPV 506_ ISTVI 511_ QNYSI 516_ NEVFL 521_ FFSKI 526_ ESNLS 531_ QPHCV 536_ FWDFS 541_ HLQWN 546_ DAGCH 551_ LVNET 556_ QDIVT 561_ CQCTH 566_ LTSFS 571_ ILMSP 576_ FVPST 581_ IFPVV 586_ KWITY 591_ VGLGI 596_ SIGSL 601_ ILCLI 606_ IEALF 611_ WKQIK 616_ KSQTS 621_ HTRRI 626_ CMVNI 631_ ALSLL 636_ IADVW 641_ FIVGA 646_ TVDTT 651_ VNPSG 656_ VCTAA 661_ VFFTH 666_ FFYLS 671_ LFFWM 676_ LMLGI 681_ LLAYR 686_ IILVF 691_ HHMAQ 696_ HLMMA 701_ VGFCL 706_ GYGCP 711_ LIISV 716_ ITIAV 721_ TQPSN 726_ TYKRK 731_ DVCWL 736_ NWSNG 741_ SKPLL 746_ AFVVP 751_ ALAIV 756_ AVNFV 761_ VVLLV 766_ LTKLW 771_ RPTVG 776_ ERLSR 781_ DDKAT 786_ IIRVG 791_ KSLLI 796_ LTPLL 801_ GLTWG 806_ FGIGT 811_ IVDSQ 816_ NLAWH 821_ VIFAL 826_ LNAFQ 831_ GFFIL 836_ CFGIL 841_ LDSKL 846_ RQLLF 851_ NKLSA 856_ LSSWK 861_ QTEKQ 866_ NSSDL 871_ SAKPK 876_ FSKPF 881_ NPLQN 886_ KGHYA 891_ FSHTG 896_ DSSDN 901_IMLTQ
1: Adhesion G-protein coupled receptor (aGPCR) for N-docosahexaenoylethanolamine (synaptamide), an omega-3 fatty acid lipid highly enriched in the brain (PubMed:27759003, PubMed:32144388). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:35418679, PubMed:36127364, PubMed:37120430). ADGRF1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:35418679). Also able to couple to G(q), G(i) and G(12)/G(13) G proteins; additional evidence is however required to confirm this result in vivo (PubMed:36127364, PubMed:37120430). Involved in the development of neurons and cognitive function (By similarity). In liver, involved in fat accumulation (By similarity)