PHD finger protein 19 (Polycomb-like protein 3) (hPCL3)
1_MENRA 6_ LDPGT 11_ RDSYG 16_ ATSHL 21_ PNKGA 26_ LAKVK 31_ NNFKD 36_ LMSKL 41_ TEGQY 46_ VLCRW 51_ TDGLY 56_ YLGKI 61_ KRVSS 66_ SKQSC 71_ LVTFE 76_ DNSKY 81_ WVLWK 86_ DIQHA 91_ GVPGE 96_ EPKCN 101_ ICLGK 106_ TSGPL 111_ NEILI 116_ CGKCG 121_ LGYHQ 126_ QCHIP 131_ IAGSA 136_ DQPLL 141_ TPWFC 146_ RRCIF 151_ ALAVR 156_ KGGAL 161_ KKGAI 166_ ARTLQ 171_ AVKMV 176_ LSYQP 181_ EELEW 186_ DSPHR 191_ TNQQQ 196_ CYCYC 201_ GGPGE 206_ WYLRM 211_ LQCYR 216_ CRQWF 221_ HEACT 226_ QCLNE 231_ PMMFG 236_ DRFYL 241_ FFCSV 246_ CNQGP 251_ EYIER 256_ LPLRW 261_ VDVVH 266_ LALYN 271_ LGVQS 276_ KKKYF 281_ DFEEI 286_ LAFVN 291_ HHWEL 296_ LQLGK 301_ LTSTP 306_ VTDRG 311_ PHLLN 316_ ALNSY 321_ KSRFL 326_ CGKEI 331_ KKKKC 336_ IFRLR 341_ IRVPP 346_ NPPGK 351_ LLPDK 356_ GLLPN 361_ ENSAS 366_ SELRK 371_ RGKSK 376_ PGLLP 381_ HEFQQ 386_ QKRRV 391_ YRRKR 396_ SKFLL 401_ EDAIP 406_ SSDFT 411_ SAWST 416_ NHHLA 421_ SIFDF 426_ TLDEI 431_ QSLKS 436_ ASSGQ 441_ TFFSD 446_ VDSTD 451_ AASTS 456_ GSAST 461_ SLSYD 466_ SRWTV 471_ GSRKR 476_ KLAAK 481_ AYMPL 486_ RAKRW 491_ AAELD 496_ GRCPS 501_ DSSAE 506_ GASVP 511_ ERPDE 516_ GIDSH 521_ TFESI 526_ SEDDS 531_ SLSHL 536_ KSSIT 541_ NYFGA 546_ AGRLA 551_ CGEKY 556_ QVLAR 561_ RVTPE 566_ GKVQY 571_LVEWE
1: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23104054, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:31959557). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (PubMed:23104054). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter (PubMed:15563832)