G-protein coupled receptor family C group 6 member A (hGPRC6A) (G-protein coupled receptor GPCR33) (hGPCR33)
1_MAFLI 6_ ILITC 11_ FVIIL 16_ ATSQP 21_ CQTPD 26_ DFVAA 31_ TSPGH 36_ IIIGG 41_ LFAIH 46_ EKMLS 51_ SEDSP 56_ RRPQI 61_ QECVG 66_ FEISV 71_ FLQTL 76_ AMIHS 81_ IEMIN 86_ NSTLL 91_ PGVKL 96_ GYEIY 101_ DTCTE 106_ VTVAM 111_ AATLR 116_ FLSKF 121_ NCSRE 126_ TVEFK 131_ CDYSS 136_ YMPRV 141_ KAVIG 146_ SGYSE 151_ ITMAV 156_ SRMLN 161_ LQLMP 166_ QVGYE 171_ STAEI 176_ LSDKI 181_ RFPSF 186_ LRTVP 191_ SDFHQ 196_ IKAMA 201_ HLIQK 206_ SGWNW 211_ IGIIT 216_ TDDDY 221_ GRLAL 226_ NTFII 231_ QAEAN 236_ NVCIA 241_ FKEVL 246_ PAFLS 251_ DNTIE 256_ VRINR 261_ TLKKI 266_ ILEAQ 271_ VNVIV 276_ VFLRQ 281_ FHVFD 286_ LFNKA 291_ IEMNI 296_ NKMWI 301_ ASDNW 306_ STATK 311_ ITTIP 316_ NVKKI 321_ GKVVG 326_ FAFRR 331_ GNISS 336_ FHSFL 341_ QNLHL 346_ LPSDS 351_ HKLLH 356_ EYAMH 361_ LSACA 366_ YVKDT 371_ DLSQC 376_ IFNHS 381_ QRTLA 386_ YKANK 391_ AIERN 396_ FVMRN 401_ DFLWD 406_ YAEPG 411_ LIHSI 416_ QLAVF 421_ ALGYA 426_ IRDLC 431_ QARDC 436_ QNPNA 441_ FQPWE 446_ LLGVL 451_ KNVTF 456_ TDGWN 461_ SFHFD 466_ AHGDL 471_ NTGYD 476_ VVLWK 481_ EINGH 486_ MTVTK 491_ MAEYD 496_ LQNDV 501_ FIIPD 506_ QETKN 511_ EFRNL 516_ KQIQS 521_ KCSKE 526_ CSPGQ 531_ MKKTT 536_ RSQHI 541_ CCYEC 546_ QNCPE 551_ NHYTN 556_ QTDMP 561_ HCLLC 566_ NNKTH 571_ WAPVR 576_ STMCF 581_ EKEVE 586_ YLNWN 591_ DSLAI 596_ LLLIL 601_ SLLGI 606_ IFVLV 611_ VGIIF 616_ TRNLN 621_ TPVVK 626_ SSGGL 631_ RVCYV 636_ ILLCH 641_ FLNFA 646_ STSFF 651_ IGEPQ 656_ DFTCK 661_ TRQTM 666_ FGVSF 671_ TLCIS 676_ CILTK 681_ SLKIL 686_ LAFSF 691_ DPKLQ 696_ KFLKC 701_ LYRPI 706_ LIIFT 711_ CTGIQ 716_ VVICT 721_ LWLIF 726_ AAPTV 731_ EVNVS 736_ LPRVI 741_ ILECE 746_ EGSIL 751_ AFGTM 756_ LGYIA 761_ ILAFI 766_ CFIFA 771_ FKGKY 776_ ENYNE 781_ AKFIT 786_ FGMLI 791_ YFIAW 796_ ITFIP 801_ IYATT 806_ FGKYV 811_ PAVEI 816_ IVILI 821_ SNYGI 826_ LYCTF 831_ IPKCY 836_ VIICK 841_ QEINT 846_ KSAFL 851_ KMIYS 856_ YSSHS 861_ VSSIA 866_ LSPAS 871_ LDSMS 876_ GNVTM 881_ TNPSS 886_ SGKSA 891_ TWQKS 896_ KDLQA 901_ QAFAH 906_ ICREN 911_ ATSVS 916_ KTLPR 921_KRMSS
1: Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations (PubMed:15576628). Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids (PubMed:15576628). The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+) (By similarity). Seems to act through a G(q)/G(11) and G(i)-coupled pathway (By similarity). Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (By similarity). Mediates the non-genomic effects of androgens in multiple tissue (By similarity). May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (PubMed:20947496)