Adipolin (Adipose-derived insulin-sensitizing factor) (C1q and TNF related protein 12) (Complement C1q tumor necrosis factor-related protein 12) [Cleaved into: Adipolin fC1QTNF12 (Adipolin fCTRP12) (Adipolin full-length form); Adipolin gC1QTNF12 (Adipolin cleaved form) (Adipolin gCTRP12)]
1_MRRWA 6_ WAAVV 11_ VLLGP 16_ QLVLL 21_ GGVGA 26_ RREAQ 31_ RTQQP 36_ GQRAD 41_ PPNAT 46_ ASASS 51_ REGLP 56_ EAPKP 61_ SQASG 66_ PEFSD 71_ AHMTW 76_ LNFVR 81_ RPDDG 86_ ALRKR 91_ CGSRD 96_ KKPRD 101_ LFGPP 106_ GPPGA 111_ EVTAE 116_ TLLHE 121_ FQELL 126_ KEATE 131_ RRFSG 136_ LLDPL 141_ LPQGA 146_ GLRLV 151_ GEAFH 156_ CRLQG 161_ PRRVD 166_ KRTLV 171_ ELHGF 176_ QAPAA 181_ QGAFL 186_ RGSGL 191_ SLASG 196_ RFTAP 201_ VSGIF 206_ QFSAS 211_ LHVDH 216_ SELQG 221_ KARLR 226_ ARDVV 231_ CVLIC 236_ IESLC 241_ QRHTC 246_ LEAVS 251_ GLESN 256_ SRVFT 261_ LQVQG 266_ LLQLQ 271_ AGQYA 276_ SVFVD 281_ NGSGA 286_ VLTIQ 291_ AGSSF 296_SGLLL
1: Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue