Probable G-protein coupled receptor 158
1_MGAMA 6_ YPLLL 11_ CLLLA 16_ QLGLG 21_ AVGAS 26_ RDPQG 31_ RPDSP 36_ RERTP 41_ KGKPH 46_ AQQPG 51_ RASAS 56_ DSSAP 61_ WSRST 66_ DGTIL 71_ AQKLA 76_ EEVPM 81_ DVASY 86_ LYTGD 91_ SHQLK 96_ RANCS 101_ GRYEL 106_ AGLPG 111_ KWPAL 116_ ASAHP 121_ SLHRA 126_ LDTLT 131_ HATNF 136_ LNVML 141_ QSNKS 146_ REQNL 151_ QDDLD 156_ WYQAL 161_ VWSLL 166_ EGEPS 171_ ISRAA 176_ ITFST 181_ DSLSA 186_ PAPQV 191_ FLQAT 196_ REESR 201_ ILLQD 206_ LSSSA 211_ PHLAN 216_ ATLET 221_ EWFHG 226_ LRRKW 231_ RPHLH 236_ RRGPN 241_ QGPRG 246_ LGHSW 251_ RRKDG 256_ LGGDK 261_ SHFKW 266_ SPPYL 271_ ECENG 276_ SYKPG 281_ WLVTL 286_ SSAIY 291_ GLQPN 296_ LVPEF 301_ RGVMK 306_ VDINL 311_ QKVDI 316_ DQCSS 321_ DGWFS 326_ GTHKC 331_ HLNNS 336_ ECMPI 341_ KGLGF 346_ VLGAY 351_ ECICK 356_ AGFYH 361_ PGVLP 366_ VNNFR 371_ RRGPD 376_ QHISG 381_ STKDV 386_ SEEAY 391_ VCLPC 396_ REGCP 401_ FCADD 406_ SPCFV 411_ QEDKY 416_ LRLAI 421_ ISFQA 426_ LCMLL 431_ DFVSM 436_ LVVYH 441_ FRKAK 446_ SIRAS 451_ GLILL 456_ ETILF 461_ GSLLL 466_ YFPVV 471_ ILYFE 476_ PSTFR 481_ CILLR 486_ WARLL 491_ GFATV 496_ YGTVT 501_ LKLHR 506_ VLKVF 511_ LSRTA 516_ QRIPY 521_ MTGGR 526_ VMRML 531_ AVILL 536_ VVFWF 541_ LIGWT 546_ SSVCQ 551_ NLEKQ 556_ ISLIG 561_ QGKTS 566_ DHLIF 571_ NMCLI 576_ DRWDY 581_ MTAVA 586_ EFLFL 591_ LWGVY 596_ LCYAV 601_ RTVPS 606_ AFHEP 611_ RYMAV 616_ AVHNE 621_ LIISA 626_ IFHTI 631_ RFVLA 636_ SRLQS 641_ DWMLM 646_ LYFAH 651_ THLTV 656_ TVTIG 661_ LLLIP 666_ KFSHS 671_ SNNPR 676_ DDIAT 681_ EAYED 686_ ELDMG 691_ RSGSY 696_ LNSSI 701_ NSAWS 706_ EHSLD 711_ PEDIR 716_ DELKK 721_ LYAQL 726_ EIYKR 731_ KKMIT 736_ NNPHL 741_ QKKRC 746_ SKKGL 751_ GRSIM 756_ RRITE 761_ IPETV 766_ SRQCS 771_ KEDKE 776_ GADHG 781_ TAKGT 786_ ALIRK 791_ NPPES 796_ SGNTG 801_ KSKEE 806_ TLKNR 811_ VFSLK 816_ KSHST 821_ YDHVR 826_ DQTEE 831_ SSSLP 836_ TESQE 841_ EETTE 846_ NSTLE 851_ SLSGK 856_ KLTQK 861_ LKEDS 866_ EAEST 871_ ESVPL 876_ VCKSA 881_ SAHNL 886_ SSEKK 891_ TGHPR 896_ TSMLQ 901_ KSLSV 906_ IASAK 911_ EKTLG 916_ LAGKT 921_ QTAGV 926_ EERTK 931_ SQKPL 936_ PKDKE 941_ TNRNH 946_ SNSDN 951_ TETKD 956_ PAPQN 961_ SNPAE 966_ EPRKP 971_ QKSGI 976_ MKQQR 981_ VNPTT 986_ ANSDL 991_ NPGTT 996_ QMKDN 1001_ FDIGE 1006_ VCPWE 1011_ VYDLT 1016_ PGPVP 1021_ SESKV 1026_ QKHVS 1031_ IVASE 1036_ MEKNP 1041_ TFSLK 1046_ EKSHH 1051_ KPKAA 1056_ EVCQQ 1061_ SNQKR 1066_ IDKAE 1071_ VCLWE 1076_ SQGQS 1081_ ILEDE 1086_ KLLIS 1091_ KTPVL 1096_ PERAK 1101_ EENGG 1106_ QPRAA 1111_ NVCAG 1116_ QSEEL 1121_ PPKAV 1126_ ASKTE 1131_ NENLN 1136_ QIGHQ 1141_ EKKTS 1146_ SSEEN 1151_ VRGSY 1156_ NSSNN 1161_ FQQPL 1166_ TSRAE 1171_ VCPWE 1176_ FETPA 1181_ QPNAG 1186_ RSVAL 1191_ PASSA 1196_ LSANK 1201_ IAGPR 1206_KEEIW
1: Metabotropic receptor for glycine that controls synapse formation and function in the brain (PubMed:36996198). Acts as an atypical G-protein coupled receptor that recruits and regulates the RGS7-GNB5 complex instead of activating G proteins (PubMed:31189666, PubMed:36996198). In absence of glycine ligand, promotes the GTPase activator activity of RGS7, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:36996198). Glycine-binding changes the conformation of the intracellular surface, inhibiting the GTPase activator activity of the RGS7-GNB5 complex, promoting G protein alpha subunits into their active GTP-bound form and regulating cAMP levels (PubMed:36996198). Also able to bind taurine, a compound closely related to glycine, but with a two-fold lower affinity (PubMed:36996198). Glycine receptor-dependent regulation of cAMP controls key ion channels, kinases and neurotrophic factors involved in neuronal excitability and synaptic transmission (PubMed:36996198). Plays a pivotal role in regulating mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Also involved in spatial learning by regulating hippocampal CA1 neuronal excitability (By similarity). Acts as a synaptic organizer in the hippocampus, required for proper mossy fiber-CA3 neurocircuitry establishment, structure and function: induces presynaptic differentiation in contacting axons via its interaction with GPC4 (By similarity). In addition to glycine, may also act as a receptor for osteocalcin (BGLAP) hormone: osteocalcin-binding initiates a signaling response that prevents neuronal apoptosis in the hippocampus and regulates the synthesis of neurotransmitters (By similarity)