Small RNA 2'-O-methyltransferase (EC 2.1.1.n8) (HEN1 methyltransferase homolog 1)
1_MEENN 6_ LQCSS 11_ VVDGN 16_ FEEVP 21_ RETAI 26_ QFKPP 31_ LYRQR 36_ YQFVK 41_ NLVDQ 46_ HEPKK 51_ VADLG 56_ CGDTS 61_ LLRLL 66_ KVNPC 71_ IELLV 76_ GVDIN 81_ EDKLR 86_ WRGDS 91_ LAPFL 96_ GDFLK 101_ PRDLN 106_ LTITL 111_ YHGSV 116_ VERDS 121_ RLLGF 126_ DLITC 131_ IELIE 136_ HLDSG 141_ DLARF 146_ PEVVF 151_ GYLSP 156_ SMIVI 161_ STPNS 166_ EFNPL 171_ FPSVT 176_ LRDSD 181_ HKFEW 186_ TRMEF 191_ QTWAL 196_ YVANR 201_ YDYSV 206_ EFTGV 211_ GEPPA 216_ GAENV 221_ GYCTQ 226_ IGIFR 231_ KNGGK 236_ ATESC 241_ LSEQH 246_ DQHVY 251_ KAVFT 256_ TSYPS 261_ LQQER 266_ FFKLV 271_ LVNEV 276_ SQQVE 281_ SLRVS 286_ HLPRR 291_ KEQAG 296_ ERGDK 301_ PKDIG 306_ GSKAP 311_ VPCFG 316_ PVFTE 321_ VEKAK 326_ IENSP 331_ TPFCV 336_ GDKFF 341_ VPLQR 346_ LLAYP 351_ KLNRL 356_ CANEE 361_ MMRSV 366_ IADSI 371_ PLSSD 376_ GSAVV 381_ ADLRN 386_YFDEQ
1: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis