Protein FAM102A (Early estrogen-induced gene 1 protein)
1_MAFLM 6_ KKKKF 11_ KFQTT 16_ FTLEE 21_ LTAVP 26_ FVNGV 31_ LFCKV 36_ RLLDG 41_ GDFVS 46_ LSSRE 51_ EVQEN 56_ CVRWR 61_ KRFTF 66_ VCKMS 71_ ANPAT 76_ GLLDP 81_ CVFRV 86_ SVRKE 91_ LKGGK 96_ AYSKL 101_ GFADL 106_ NLAEF 111_ AGSGS 116_ TVRCC 121_ LLEGY 126_ DTKNT 131_ RQDNS 136_ ILKVT 141_ IGMFL 146_ LSGDP 151_ CFKTP 156_ PSTAK 161_ SISIP 166_ GQDSS 171_ LQLTC 176_ KGGGT 181_ SSGGS 186_ STNSL 191_ TGSRP 196_ PKARP 201_ TILSS 206_ GLPEE 211_ PDQNL 216_ SSPEE 221_ VFHSG 226_ HSRNS 231_ SYASQ 236_ QSKIS 241_ GYSTE 246_ HSRSS 251_ SLSDL 256_ THRRN 261_ TSTSS 266_ SASGG 271_ LGMTV 276_ EGPEG 281_ SEREH 286_ RPPEK 291_ PPRPP 296_ RPLHL 301_ SDRSF 306_ RRKKD 311_ SVESH 316_ PTWVD 321_ DTRID 326_ ADAIV 331_ EKIVQ 336_ SQDFT 341_ DGSNT 346_ EDSNL 351_ RLFVS 356_ RDGSA 361_ TLSGI 366_ QLATR 371_ VSSGV 376_YEPVV
1: Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097)