Armadillo repeat-containing protein 12
1_MGKSI 6_ PQYLG 11_ QLDIR 16_ KSVVS 21_ LATGA 26_ GAIYL 31_ LYKAI 36_ KAGIK 41_ CKPPL 46_ CSNSP 51_ ICIAR 56_ LAVER 61_ ERHGR 66_ DSGEL 71_ RRLLN 76_ SLECK 81_ QDEYA 86_ KSMIL 91_ HSITR 96_ CVYLL 101_ EAEAS 106_ ACTTD 111_ DIVLL 116_ GYMLD 121_ DKDNS 126_ VKTQA 131_ LNTLK 136_ AFSGI 141_ RKFRL 146_ KIQEH 151_ SIKVL 156_ ELIST 161_ IWDTE 166_ LHIAG 171_ LRLLN 176_ NLPLP 181_ DYVHP 186_ QLRRV 191_ MPALM 196_ EILQS 201_ DYILA 206_ QVQAV 211_ RLLSY 216_ LAQKN 221_ DLLYD 226_ ILNCQ 231_ VHSNF 236_ LNLFQ 241_ PTQSG 246_ SLLYE 251_ VLVFA 256_ ERLSE 261_ GRNAP 266_ HYHVV 271_ KWHYN 276_ EQSLH 281_ ESLFG 286_ EESRL 291_ ADRLL 296_ ALVIH 301_ PEEDV 306_ QIQAC 311_ KVIVS 316_ LQYPQ 321_ DLRAR 326_ PSSCQ 331_PSRSY
1: Essential for male fertility and sperm mitochondrial sheath formation (By similarity). Required for proper mitochondrial elongation and coiling along the flagellum during the formation of the mitochondrial sheath (By similarity). Facilitates the growth and aggressiveness of neuroblastoma cells (PubMed:30026490). Increases the EZH2 activity and H3K27me3 levels in a RBBP4-dependent manner, and facilitates the enrichment of polycomb repressive complex 2 and H3K27me3 on gene promoters, resulting in transcriptional repression of tumor suppressors affecting the proliferation, invasion, and metastasis of tumor cells (PubMed:30026490)