Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) (Protein related to CPSF subunits of 68 kDa) (RC-68)
1_MPEIR 6_ VTPLG 11_ AGQDV 16_ GRSCI 21_ LVSIA 26_ GKNVM 31_ LDCGM 36_ HMGFN 41_ DDRRF 46_ PDFSY 51_ ITQNG 56_ RLTDF 61_ LDCVI 66_ ISHFH 71_ LDHCG 76_ ALPYF 81_ SEMVG 86_ YDGPI 91_ YMTHP 96_ TQAIC 101_ PILLE 106_ DYRKI 111_ AVDKK 116_ GEANF 121_ FTSQM 126_ IKDCM 131_ KKVVA 136_ VHLHQ 141_ TVQVD 146_ DELEI 151_ KAYYA 156_ GHVLG 161_ AAMFQ 166_ IKVGS 171_ ESVVY 176_ TGDYN 181_ MTPDR 186_ HLGAA 191_ WIDKC 196_ RPNLL 201_ ITEST 206_ YATTI 211_ RDSKR 216_ CRERD 221_ FLKKV 226_ HETVE 231_ RGGKV 236_ LIPVF 241_ ALGRA 246_ QELCI 251_ LLETF 256_ WERMN 261_ LKVPI 266_ YFSTG 271_ LTEKA 276_ NHYYK 281_ LFIPW 286_ TNQKI 291_ RKTFV 296_ QRNMF 301_ EFKHI 306_ KAFDR 311_ AFADN 316_ PGPMV 321_ VFATP 326_ GMLHA 331_ GQSLQ 336_ IFRKW 341_ AGNEK 346_ NMVIM 351_ PGYCV 356_ QGTVG 361_ HKILS 366_ GQRKL 371_ EMEGR 376_ QVLEV 381_ KMQVE 386_ YMSFS 391_ AHADA 396_ KGIMQ 401_ LVGQA 406_ EPESV 411_ LLVHG 416_ EAKKM 421_ EFLKQ 426_ KIEQE 431_ LRVNC 436_ YMPAN 441_ GETVT 446_ LPTSP 451_ SIPVG 456_ ISLGL 461_ LKREM 466_ AQGLL 471_ PEAKK 476_ PRLLH 481_ GTLIM 486_ KDSNF 491_ RLVSS 496_ EQALK 501_ ELGLA 506_ EHQLR 511_ FTCRV 516_ HLHDT 521_ RKEQE 526_ TALRV 531_ YSHLK 536_ SVLKD 541_ HCVQH 546_ LPDGS 551_ VTVES 556_ VLLQA 561_ AAPSE 566_ DPGTK 571_ VLLVS 576_ WTYQD 581_ EELGS 586_ FLTSL 591_LKKGL
1: RNA endonuclease component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:16239144, PubMed:25201415, PubMed:28396433, PubMed:32697989, PubMed:33243860, PubMed:33548203, PubMed:34762484, PubMed:37080207, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:32697989, PubMed:33243860, PubMed:33548203, PubMed:34762484, PubMed:37080207, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:22252320, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS11 constitutes the RNA endonuclease subunit that degrades exiting nascent RNA transcripts (PubMed:28396433, PubMed:32697989, PubMed:33243860, PubMed:33548203, PubMed:34762484, PubMed:37080207, PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267)