Ceramide-1-phosphate transfer protein (CPTP) (Glycolipid transfer protein domain-containing protein 1) (GLTP domain-containing protein 1)
1_MDDSE 6_ TGFNL 11_ KVVLV 16_ SFKQC 21_ LDEKE 26_ EVLLD 31_ PYIAS 36_ WKGLV 41_ RFLNS 46_ LGTIF 51_ SFISK 56_ DVVSK 61_ LRIME 66_ RLRGG 71_ PQSEH 76_ YRSLQ 81_ AMVAH 86_ ELSNR 91_ LVDLE 96_ RRSHH 101_ PESGC 106_ RTVLR 111_ LHRAL 116_ HWLQL 121_ FLEGL 126_ RTSPE 131_ DARTS 136_ ALCAD 141_ SYNAS 146_ LAAYH 151_ PWVVR 156_ RAVTV 161_ AFCTL 166_ PTREV 171_ FLEAM 176_ NVGPP 181_ EQAVQ 186_ MLGEA 191_ LPFIQ 196_ RVYNV 201_ SQKLY 206_AEHSL
1: Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (PubMed:28011644). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed:29164996)