Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11)
1_MEESK 6_ TLKSE 11_ NHEPK 16_ KNVIC 21_ EESKA 26_ VQVIG 31_ NQTLK 36_ ARNDK 41_ SVKEI 46_ ENSSP 51_ NRNSS 56_ KKNKQ 61_ NDICI 66_ EKTEV 71_ KSCKV 76_ NAANL 81_ PGPKD 86_ LGLVL 91_ RDQSH 96_ CKAKK 101_ FPNSP 106_ VKAEK 111_ ATISQ 116_ AKSEK 121_ ATSLQ 126_ AKAEK 131_ SPKSP 136_ NSVKA 141_ EKASS 146_ YQMKS 151_ EKVPS 156_ SPAEA 161_ EKGPS 166_ LLLKD 171_ MRQKT 176_ ELQQI 181_ GKKIP 186_ SSFTS 191_ VDKVN 196_ IEAVG 201_ GEKCA 206_ LQNSP 211_ RSQKQ 216_ QTCTD 221_ NTGDS 226_ DDSAS 231_ GIEDV 236_ SDDLS 241_ KMKND 246_ ESNKE 251_ NSSEM 256_ DYLEN 261_ ATVID 266_ ESALT 271_ PEQRL 276_ GLKQA 281_ EERLE 286_ RDHIF 291_ RLEKR 296_ SPEYT 301_ NCRYL 306_ CKLCL 311_ IHIEN 316_ IQGAH 321_ KHIKE 326_ KRHKK 331_ NILEK 336_ QEESE 341_ LRSLP 346_ PPSPA 351_ HLAAL 356_ SVAVI 361_ ELAKE 366_ HGITD 371_ DDLRV 376_ RQEIV 381_ EEMSK 386_ VITTF 391_ LPECS 396_ LRLYG 401_ SSLTR 406_ FALKS 411_ SDVNI 416_ DIKFP 421_ PKMNH 426_ PDLLI 431_ KVLGI 436_ LKKNV 441_ LYVDV 446_ ESDFH 451_ AKVPV 456_ VVCRD 461_ RKSGL 466_ LCRVS 471_ AGNDM 476_ ACLTT 481_ DLLTA 486_ LGKIE 491_ PVFIP 496_ LVLAF 501_ RYWAK 506_ LCYID 511_ SQTDG 516_ GIPSY 521_ CFALM 526_ VMFFL 531_ QQRKP 536_ PLLPC 541_ LLGSW 546_ IEGFD 551_ PKRMD 556_ DFQLK 561_ GIVEE 566_ KFVKW 571_ ECNSS 576_ SATEK 581_ NSIAE 586_ ENKAK 591_ ADQPK 596_ DDTKK 601_ TETDN 606_ QSNAM 611_ KEKHG 616_ KSPLA 621_ LETPN 626_ RVSLG 631_ QLWLE 636_ LLKFY 641_ TLDFA 646_ LEEYV 651_ ICVRI 656_ QDILT 661_ RENKN 666_ WPKRR 671_ IAIED 676_ PFSVK 681_ RNVAR 686_ SLNSQ 691_ LVYEY 696_ VVERF 701_ RAAYR 706_ YFACP 711_ QTKGG 716_ NKSTV 721_ DFKKR 726_ EKGKI 731_ SNKKP 736_ VKSNN 741_ MATNG 746_ CILLG 751_ ETTEK 756_ INAER 761_ EQPVQ 766_ CDEMD 771_ CTSQR 776_ CIIDN 781_ NNLLV 786_ NELDF 791_ ADHGQ 796_ DSSSL 801_ STSKS 806_ SEIEP 811_ KLDKK 816_ QDDLA 821_ PSETC 826_ LKKEL 831_ SQCNC 836_ IDLSK 841_ SPDPD 846_ KSTGT 851_ DCRSN 856_ LETES 861_ SHQSV 866_ CTDTS 871_ ATSCN 876_ CKATE 881_ DASDL 886_ NDDDN 891_ LPTQE 896_ LYYVF 901_ DKFIL 906_ TSGKP 911_ PTIVC 916_ SICKK 921_ DGHSK 926_ NDCPE 931_ DFRKI 936_ DLKPL 941_ PPMTN 946_ RFREI 951_ LDLVC 956_ KRCFD 961_ ELSPP 966_ CSEQH 971_ NREQI 976_ LIGLE 981_ KFIQK 986_ EYDEK 991_ ARLCL 996_ FGSSK 1001_ NGFGF 1006_ RDSDL 1011_ DICMT 1016_ LEGHE 1021_ NAEKL 1026_ NCKEI 1031_ IENLA 1036_ KILKR 1041_ HPGLR 1046_ NILPI 1051_ TTAKV 1056_ PIVKF 1061_ EHRRS 1066_ GLEGD 1071_ ISLYN 1076_ TLAQH 1081_ NTRML 1086_ ATYAA 1091_ IDPRV 1096_ QYLGY 1101_ TMKVF 1106_ AKRCD 1111_ IGDAS 1116_ RGSLS 1121_ SYAYI 1126_ LMVLY 1131_ FLQQR 1136_ KPPVI 1141_ PVLQE 1146_ IFDGK 1151_ QIPQR 1156_ MVDGW 1161_ NAFFF 1166_ DKTEE 1171_ LKKRL 1176_ PSLGK 1181_ NTESL 1186_ GELWL 1191_ GLLRF 1196_ YTEEF 1201_ DFKEY 1206_ VISIR 1211_ QKKLL 1216_ TTFEK 1221_ QWTSK 1226_ CIAIE 1231_ DPFDL 1236_ NHNLG 1241_ AGVSR 1246_ KMTNF 1251_ IMKAF 1256_ INGRK 1261_ LFGTP 1266_ FYPLI 1271_ GREAE 1276_ YFFDS 1281_ RVLTD 1286_ GELAP 1291_ NDRCC 1296_ RVCGK 1301_ IGHYM 1306_ KDCPK 1311_ RKSLL 1316_ FRLKK 1321_ KDSEE 1326_ EKEGN 1331_ EEEKD 1336_ SRDVL 1341_ DPRDL 1346_ HDTRD 1351_ FRDPR 1356_ DLRCF 1361_ ICGDA 1366_ GHVRR 1371_ ECPEV 1376_ KLARQ 1381_ RNSSV 1386_ AAAQL 1391_ VRNLV 1396_ NAQQV 1401_ AGSAQ 1406_ QQGDQ 1411_ SIRTR 1416_ QSSEC 1421_ SESPS 1426_ YSPQP 1431_ QPFPQ 1436_ NSSQS 1441_ AAITQ 1446_ PSSQP 1451_ GSQPK 1456_ LGPPQ 1461_ QGAQP 1466_ PHQVQ 1471_ MPLYN 1476_ FPQSP 1481_ PAQYS 1486_ PMHNM 1491_ GLLPM 1496_ HPLQI 1501_ PAPSW 1506_ PIHGP 1511_ VIHSA 1516_ PGSAP 1521_ SNIGL 1526_ NDPSI 1531_ IFAQP 1536_ AARPV 1541_ AIPNT 1546_ SHDGH 1551_ WPRTV 1556_ APNSL 1561_ VNSGA 1566_ VGNSE 1571_ PGFRG 1576_ LTPPI 1581_ PWEHA 1586_ PRPHF 1591_ PLVPA 1596_ SWPYG 1601_ LHQNF 1606_ MHQGN 1611_ ARFQP 1616_ NKPFY 1621_ TQDRC 1626_ ATRRC 1631_ RERCP 1636_HPPRG
1: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:16643855, PubMed:18172165, PubMed:19703396, PubMed:25480299, PubMed:25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351)