Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198)
1_MPVQA 6_ PQWTD 11_ FLSCP 16_ ICTQT 21_ FDETI 26_ RKPIS 31_ LGCGH 36_ TVCKM 41_ CLNKL 46_ HRKAC 51_ PFDQT 56_ TINTD 61_ IELLP 66_ VNSAL 71_ LQLVG 76_ AQVPE 81_ QQPIT 86_ LCSGV 91_ EDTKH 96_ YEEAK 101_ KCVEE 106_ LALYL 111_ KPLSS 116_ ARGVG 121_ LNSTT 126_ QSVLS 131_ RPMQR 136_ KLVTL 141_ VHCQL 146_ VEEEG 151_ RIRAM 156_ RAARS 161_ LGERT 166_ VTELI 171_ LQHQN 176_ PQQLS 181_ SNLWA 186_ AVRAR 191_ GCQFL 196_ GPAMQ 201_ EEALK 206_ LVLLA 211_ LEDGS 216_ ALSRK 221_ VLVLF 226_ VVQRL 231_ EPRFP 236_ QASKT 241_ SIGHV 246_ VQLLY 251_ RASCF 256_ KVTKR 261_ DEDSS 266_ LMQLK 271_ EEFRT 276_ YEALR 281_ REHDS 286_ QIVQI 291_ AMEAG 296_ LRIAP 301_ DQWSS 306_ LLYGD 311_ QSHKS 316_ HMQSI 321_ IDKLQ 326_ TPASF 331_ AQSVQ 336_ ELTIA 341_ LQRTG 346_ DPANL 351_ NRLRP 356_ HLELL 361_ ANIDP 366_ SPDAP 371_ PPTWE 376_ QLENG 381_ LVAVR 386_ TVVHG 391_ LVDYI 396_ QNHSK 401_ KGADQ 406_ QQPPQ 411_ HSKYK 416_ TYMCR 421_ DMKQR 426_ GGCPR 431_ GASCT 436_ FAHSQ 441_ EELEK 446_ FRKMN 451_ KRLVP 456_ RRPLS 461_ ASLGQ 466_ LNEVG 471_ LPSAA 476_ ILPDE 481_ GAVDL 486_ PSRKP 491_ PALPN 496_ GIVST 501_ GNTVT 506_ QLIPR 511_ GTDPS 516_ YDSSL 521_ KPGKI 526_ DHLSS 531_ SAPGS 536_ PPDLL 541_ ESVPK 546_ SISAL 551_ PVNPH 556_ SIPPR 561_ GPADL 566_ PPMPV 571_ TKPLQ 576_ MVPRG 581_ SQLYP 586_ AQQTD 591_ VYYQD 596_ PRGAA 601_ PPFEP 606_ APYQQ 611_ GMYYT 616_ PPPQC 621_ VSRFV 626_ RPPPS 631_ APEPA 636_ PPYLD 641_ HYPPY 646_ LQERV 651_ VNSQY 656_ GTQPQ 661_ QYPPI 666_ YPSHY 671_ DGRRV 676_ YPAPS 681_ YTREE 686_ IFRES 691_ PIPIE 696_ IPPAA 701_ VPSYV 706_ PESRE 711_ RYQQI 716_ ESYYP 721_ VAPHP 726_ TQIRP 731_ SYLRE 736_ PPYSR 741_ LPPPP 746_ QPHPS 751_ LDELH 756_ RRRKE 761_ IMAQL 766_ EERKV 771_ ISPPP 776_ FAPSP 781_ TLPPT 786_ FHPEE 791_ FLDED 796_ LKVAG 801_ KYKGN 806_ DYSQY 811_ SPWSC 816_ DTIGS 821_ YIGTK 826_ DAKPK 831_ DVVAA 836_ GSVEM 841_ MNVES 846_ KGMRD 851_ QRLDL 856_ QRRAA 861_ ETSDD 866_ DLIPF 871_ GDRPT 876_ VSRFG 881_ AISRT 886_ SKTIY 891_ QGAGP 896_ MQAMA 901_ PQGAP 906_ TKSIN 911_ ISDYS 916_ PYGTH 921_ GGWGA 926_ SPYSP 931_ HQNIP 936_ SQGHF 941_ SERER 946_ ISMSE 951_ VASHG 956_ KPLPS 961_ AEREQ 966_ LRLEL 971_ QQLNH 976_ QISQQ 981_ TQLRG 986_ LEAVS 991_ NRLVL 996_ QREAN 1001_ TLAGQ 1006_ SQPPP 1011_ PPPPK 1016_ WPGMI 1021_ SSEQL 1026_ SLELH 1031_ QVERE 1036_ IGKRT 1041_ RELSM 1046_ ENQCS 1051_ LDMKS 1056_ KLNTS 1061_ KQAEN 1066_ GQPEP 1071_ QNKVP 1076_ AEDLT 1081_ LTFSD 1086_ VPNGS 1091_ ALTQE 1096_ NISLL 1101_ SNKTS 1106_ SLNLS 1111_ EDPEG 1116_ GGDNN 1121_ DSQRS 1126_GVTPS
1: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:25026078, PubMed:31636267). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:25026078, PubMed:25504471). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406, PubMed:31636267). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670)