Cytochrome P450 4A22 (CYPIVA22) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)
1_MSVSV 6_ LSPSR 11_ RLGGV 16_ SGILQ 21_ VTSLL 26_ ILLLL 31_ LIKAA 36_ QLYLH 41_ RQWLL 46_ KALQQ 51_ FPCPP 56_ SHWLF 61_ GHIQE 66_ FQHDQ 71_ ELQRI 76_ QERVK 81_ TFPSA 86_ CPYWI 91_ WGGKV 96_ RVQLY 101_ DPDYM 106_ KVILG 111_ RSDPK 116_ SHGSY 121_ KFLAP 126_ RIGYG 131_ LLLLN 136_ GQTWF 141_ QHRRM 146_ LTPAF 151_ HNDIL 156_ KPYVG 161_ LMADS 166_ VRVML 171_ DKWEE 176_ LLGQD 181_ SPLEV 186_ FQHVS 191_ LMTLD 196_ TIMKS 201_ AFSHQ 206_ GSIQV 211_ DRNSQ 216_ SYIQA 221_ ISDLN 226_ SLVFC 231_ CMRNA 236_ FHEND 241_ TIYSL 246_ TSAGR 251_ WTHRA 256_ CQLAH 261_ QHTDQ 266_ VIQLR 271_ KAQLQ 276_ KEGEL 281_ EKIKR 286_ KRHLD 291_ FLDIL 296_ LLAKM 301_ ENGSI 306_ LSDKD 311_ LRAEV 316_ DTFMF 321_ EGHDT 326_ TASGI 331_ SWILY 336_ ALATH 341_ PKHQE 346_ RCREE 351_ IHGLL 356_ GDGAS 361_ ITWNH 366_ LDQMP 371_ YTTMC 376_ IKEAL 381_ RLYPP 386_ VPGIG 391_ RELST 396_ PVTFP 401_ DGRSL 406_ PKGIM 411_ VLLSI 416_ YGLHH 421_ NPKVW 426_ PNLEV 431_ FDPSR 436_ FAPGS 441_ AQHSH 446_ AFLPF 451_ SGGSR 456_ NCIGK 461_ QFAMN 466_ QLKVA 471_ RALTL 476_ LRFEL 481_ LPDPT 486_ RIPIP 491_ MARLV 496_ LKSKN 501_ GIHLR 506_ LRRLP 511_NPCED
1: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis