Gene name: MAP3K21

Uniprot entry:

Q5TCX8

Protein names:

Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)

Protein sequence:

1_MALRG 6_ AAGAT 11_ DTPVS 16_ SAGGA 21_ PGGSA 26_ SSSST 31_ SSGGS 36_ ASAGA 41_ GLWAA 46_ LYDYE 51_ ARGED 56_ ELSLR 61_ RGQLV 66_ EVLSQ 71_ DAAVS 76_ GDEGW 81_ WAGQV 86_ QRRLG 91_ IFPAN 96_ YVAPC 101_ RPAAS 106_ PAPPP 111_ SRPSS 116_ PVHVA 121_ FERLE 126_ LKELI 131_ GAGGF 136_ GQVYR 141_ ATWQG 146_ QEVAV 151_ KAARQ 156_ DPEQD 161_ AAAAA 166_ ESVRR 171_ EARLF 176_ AMLRH 181_ PNIIE 186_ LRGVC 191_ LQQPH 196_ LCLVL 201_ EFARG 206_ GALNR 211_ ALAAA 216_ NAAPD 221_ PRAPG 226_ PRRAR 231_ RIPPH 236_ VLVNW 241_ AVQIA 246_ RGMLY 251_ LHEEA 256_ FVPIL 261_ HRDLK 266_ SSNIL 271_ LLEKI 276_ EHDDI 281_ CNKTL 286_ KITDF 291_ GLARE 296_ WHRTT 301_ KMSTA 306_ GTYAW 311_ MAPEV 316_ IKSSL 321_ FSKGS 326_ DIWSY 331_ GVLLW 336_ ELLTG 341_ EVPYR 346_ GIDGL 351_ AVAYG 356_ VAVNK 361_ LTLPI 366_ PSTCP 371_ EPFAK 376_ LMKEC 381_ WQQDP 386_ HIRPS 391_ FALIL 396_ EQLTA 401_ IEGAV 406_ MTEMP 411_ QESFH 416_ SMQDD 421_ WKLEI 426_ QQMFD 431_ ELRTK 436_ EKELR 441_ SREEE 446_ LTRAA 451_ LQQKS 456_ QEELL 461_ KRREQ 466_ QLAER 471_ EIDVL 476_ ERELN 481_ ILIFQ 486_ LNQEK 491_ PKVKK 496_ RKGKF 501_ KRSRL 506_ KLKDG 511_ HRISL 516_ PSDFQ 521_ HKITV 526_ QASPN 531_ LDKRR 536_ SLNSS 541_ SSSPP 546_ SSPTM 551_ MPRLR 556_ AIQLT 561_ SDESN 566_ KTWGR 571_ NTVFR 576_ QEEFE 581_ DVKRN 586_ FKKKG 591_ CTWGP 596_ NSIQM 601_ KDRTD 606_ CKERI 611_ RPLSD 616_ GNSPW 621_ STILI 626_ KNQKT 631_ MPLAS 636_ LFVDQ 641_ PGSCE 646_ EPKLS 651_ PDGLE 656_ HRKPK 661_ QIKLP 666_ SQAYI 671_ DLPLG 676_ KDAQR 681_ ENPAE 686_ AESWE 691_ EAASA 696_ NAATV 701_ SIEMT 706_ PTNSL 711_ SRSPQ 716_ RKKTE 721_ SALYG 726_ CTVLL 731_ ASVAL 736_ GLDLR 741_ ELHKA 746_ QAAEE 751_ PLPKE 756_ EKKKR 761_ EGIFQ 766_ RASKS 771_ RRSAS 776_ PPTSL 781_ PSTCG 786_ EASSP 791_ PSLPL 796_ SSALG 801_ ILSTP 806_ SFSTK 811_ CLLQM 816_ DSEDP 821_ LVDSA 826_ PVTCD 831_ SEMLT 836_ PDFCP 841_ TAPGS 846_ GREPA 851_ LMPRL 856_ DTDCS 861_ VSRNL 866_ PSSFL 871_ QQTCG 876_ NVPYC 881_ ASSKH 886_ RPSHH 891_ RRTMS 896_ DGNPT 901_ PTGAT 906_ IISAT 911_ GASAL 916_ PLCPS 921_ PAPHS 926_ HLPRE 931_ VSPKK 936_ HSTVH 941_ IVPQR 946_ RPASL 951_ RSRSD 956_ LPQAY 961_ PQTAV 966_ SQLAQ 971_ TACVV 976_ GRPGP 981_ HPTQF 986_ LAAKE 991_ RTKSH 996_ VPSLL 1001_ DADVE 1006_ GQSRD 1011_ YTVPL 1016_ CRMRS 1021_ KTSRP 1026_ SIYEL 1031_EKEFL

Protein annotations

Protein functions:

1: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways