SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)
1_MLAYC 6_ VQDAT 11_ VVDVE 16_ KRRNP 21_ SKHYV 26_ YIINV 31_ TWSDS 36_ TSQTI 41_ YRRYS 46_ KFFDL 51_ QMQLL 56_ DKFPI 61_ EGGQK 66_ DPKQR 71_ IIPFL 76_ PGKIL 81_ FRRSH 86_ IRDVA 91_ VKRLK 96_ PIDEY 101_ CRALV 106_ RLPPH 111_ ISQCD 116_ EVFRF 121_ FEARP 126_ EDVNP 131_ PKEDY 136_ GSSKR 141_ KSVWL 146_ SSWAE 151_ SPKKD 156_ VTGAD 161_ ATAEP 166_ MILEQ 171_ YVVVS 176_ NYKKQ 181_ ENSEL 186_ SLQAG 191_ EVVDV 196_ IEKNE 201_ SGWWF 206_ VSTSE 211_ EQGWV 216_ PATYL 221_ EAQNG 226_ TRDDS 231_ DINTS 236_ KTGEV 241_ SKRRK 246_ AHLRR 251_ LDRRW 256_ TLGGM 261_ VNRQH 266_ SREEK 271_ YVTVQ 276_ PYTSQ 281_ SKDEI 286_ GFEKG 291_ VTVEV 296_ IRKNL 301_ EGWWY 306_ IRYLG 311_ KEGWA 316_ PASYL 321_ KKAKD 326_ DLPTR 331_ KKNLA 336_ GPVEI 341_ IGNIM 346_ EISNL 351_ LNKKA 356_ SGDKE 361_ TPPAE 366_ GEGHE 371_ APIAK 376_ KEISL 381_ PILCN 386_ ASNGS 391_ AVGVP 396_ DRTVS 401_ RLAQG 406_ SPAVA 411_ RIAPQ 416_ RAQIS 421_ SPNLR 426_ TRPPP 431_ RRESS 436_ LGFQL 441_ PKPPE 446_ PPSVE 451_ VEYYT 456_ IAEFQ 461_ SCISD 466_ GISFR 471_ GGQKA 476_ EVIDK 481_ NSGGW 486_ WYVQI 491_ GEKEG 496_ WAPAS 501_ YIDKR 506_ KKPNL 511_ SRRTS 516_ TLTRP 521_ KVPPP 526_ APPSK 531_ PKEAE 536_ EGPTG 541_ ASESQ 546_ DSPRK 551_ LKYEE 556_ PEYDI 561_ PAFGF 566_ DSEPE 571_ LSEEP 576_ VEDRA 581_ SGERR 586_ PAQPH 591_ RPSPA 596_ SSLQR 601_ ARFKV 606_ GESSE 611_ DVALE 616_ EETIY 621_ ENEGF 626_ RPYAE 631_ DTLSA 636_ RGSSG 641_ DSDSP 646_ GSSSL 651_ SLTRK 656_ NSPKS 661_ GSPKS 666_ SSLLK 671_ LKAEK 676_ NAQAE 681_ MGKNH 686_ SSASF 691_ SSSIT 696_ INTTC 701_ CSSSS 706_ SSSSS 711_ LSKTS 716_ GDLKP 721_ RSASD 726_ AGIRG 731_ TPKVR 736_ AKKDA 741_ DANAG 746_ LTSCP 751_ RAKPS 756_ VRPKP 761_ FLNRA 766_ ESQSQ 771_ EKMDI 776_ STLRR 781_ QLRPT 786_ GQLRG 791_ GLKGS 796_ KSEDS 801_ ELPPQ 806_ TASEA 811_ PSEGS 816_ RRSSS 821_ DLITL 826_ PATTP 831_ PCPTK 836_ KEWEG 841_ PATSY 846_ MTCSA 851_ YQKVQ 856_ DSEIS 861_ FPAGV 866_ EVQVL 871_ EKQES 876_ GWWYV 881_ RFGEL 886_ EGWAP 891_ SHYLV 896_ LDENE 901_ QPDPS 906_ GKELD 911_ TVPAK 916_ GRQNE 921_ GKSDS 926_ LEKIE 931_ RRVQA 936_ LNTVN 941_ QSKKA 946_ TPPIP 951_ SKPPG 956_ GFGKT 961_ SGTPA 966_ VKMRN 971_ GVRQV 976_ AVRPQ 981_ SVFVS 986_ PPPKD 991_ NNLSC 996_ ALRRN 1001_ ESLTA 1006_ TDGLR 1011_ GVRRN 1016_ SSFST 1021_ ARSAA 1026_ AEAKG 1031_ RLAER 1036_ AASQG 1041_ SDSPL 1046_ LPAQR 1051_ NSIPV 1056_ SPVRP 1061_ KPIEK 1066_ SQFIH 1071_ NNLKD 1076_ VYVSI 1081_ ADYEG 1086_ DEETA 1091_ GFQEG 1096_ VSMEV 1101_ LERNP 1106_ NGWWY 1111_ CQILD 1116_ GVKPF 1121_ KGWVP 1126_SNYLE
1: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide