Protein DDI1 homolog 2 (EC 3.4.23.-)
1_MLLTV 6_ YCVRR 11_ DLSEV 16_ TFSLQ 21_ VDADF 26_ ELHNF 31_ RALCE 36_ LESGI 41_ PAAES 46_ QIVYA 51_ ERPLT 56_ DNHRS 61_ LASYG 66_ LKDGD 71_ VVILR 76_ QKENA 81_ DPRPP 86_ VQFPN 91_ LPRID 96_ FSSIA 101_ VPGTS 106_ SPRQR 111_ QPPGT 116_ QQSHS 121_ SPGEI 126_ TSSPQ 131_ GLDNP 136_ ALLRD 141_ MLLAN 146_ PHELS 151_ LLKER 156_ NPPLA 161_ EALLS 166_ GDLEK 171_ FSRVL 176_ VEQQQ 181_ DRARR 186_ EQERI 191_ RLFSA 196_ DPFDL 201_ EAQAK 206_ IEEDI 211_ RQQNI 216_ EENMT 221_ IAMEE 226_ APESF 231_ GQVVM 236_ LYINC 241_ KVNGH 246_ PVKAF 251_ VDSGA 256_ QMTIM 261_ SQACA 266_ ERCNI 271_ MRLVD 276_ RRWAG 281_ IAKGV 286_ GTQKI 291_ IGRVH 296_ LAQVQ 301_ IEGDF 306_ LPCSF 311_ SILEE 316_ QPMDM 321_ LLGLD 326_ MLKRH 331_ QCSID 336_ LKKNV 341_ LVIGT 346_ TGSQT 351_ TFLPE 356_ GELPE 361_ CARLA 366_ YGAGR 371_ EDVRP 376_ EEIAD 381_ QELAE 386_ ALQKS 391_AEDAE
1: Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27528193, PubMed:27676298). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612)