Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3)
1_MEEIL 6_ RKLQK 11_ EASGS 16_ KYKAI 21_ KESCT 26_ WALET 31_ LGGLD 36_ TIVKI 41_ PPHVL 46_ REKCL 51_ LPLQL 56_ ALESK 61_ NVKLA 66_ QHALA 71_ GMQKL 76_ LSEER 81_ FVSME 86_ TDSDE 91_ KQLLN 96_ QILNA 101_ VKVTP 106_ SLNED 111_ LQVEV 116_ MKVLL 121_ CITYT 126_ PTFDL 131_ NGSAV 136_ LKIAE 141_ VCIET 146_ YISSC 151_ HQRSI 156_ NTAVR 161_ ATLSQ 166_ MLSDL 171_ TLQLR 176_ QRQEN 181_ TIIEN 186_ PDVPQ 191_ DFGNQ 196_ GSTVE 201_ SLCDD 206_ VVSVL 211_ TVLCE 216_ KLQAA 221_ INDSQ 226_ QLQLL 231_ YLECI 236_ LSVLS 241_ SSSSS 246_ MHLHR 251_ RFTDL 256_ IWKNL 261_ CPALI 266_ VILGN 271_ PIHDK 276_ TITSA 281_ HTSST 286_ STSLE 291_ SDSAS 296_ PGVSD 301_ HGRGS 306_ GCSCT 311_ APALS 316_ GPVAR 321_ TIYYI 326_ AAELV 331_ RLVGS 336_ VDSMK 341_ PVLQS 346_ LYHRV 351_ LLYPP 356_ PQHRV 361_ EAIKI 366_ MKEIL 371_ GSPQR 376_ LCDLA 381_ GPSST 386_ ESESR 391_ KRSIS 396_ KRKSH 401_ LDLLK 406_ LIMDG 411_ MTEAC 416_ IKGGI 421_ EACYA 426_ AVSCV 431_ CTLLG 436_ ALDEL 441_ SQGKG 446_ LSEGQ 451_ VQLLL 456_ LRLEE 461_ LKDGA 466_ EWSRD 471_ SMEIN 476_ EADFR 481_ WQRRV 486_ LSSEH 491_ TPWES 496_ GNERS 501_ LDISI 506_ SVTTD 511_ TGQTT 516_ LEGEL 521_ GQTTP 526_ EDHSG 531_ NHKNS 536_ LKSPA 541_ IPEGK 546_ ETLSK 551_ VLETE 556_ AVDQP 561_ DVVQR 566_ SHTVP 571_ YPDIT 576_ NFLSV 581_ DCRTR 586_ SYGSR 591_ YSESN 596_ FSVDD 601_ QDLSR 606_ TEFDS 611_ CDQYS 616_ MAAEK 621_ DSGRS 626_ DVSDI 631_ GSDNC 636_ SLADE 641_ EQTPR 646_ DCLGH 651_ RSLRT 656_ AALSL 661_ KLLKN 666_ QEADQ 671_ HSARL 676_ FIQSL 681_ EGLLP 686_ RLLSL 691_ SNVEE 696_ VDTAL 701_ QNFAS 706_ TFCSG 711_ MMHSP 716_ GFDGN 721_ SSLSF 726_ QMLMN 731_ ADSLY 736_ TAAHC 741_ ALLLN 746_ LKLSH 751_ GDYYR 756_ KRPTL 761_ APGVM 766_ KDFMK 771_ QVQTS 776_ GVLMV 781_ FSQAW 786_ IEELY 791_ HQVLD 796_ RNMLG 801_ EAGYW 806_ GSPED 811_ NSLPL 816_ ITMLT 821_ DIDGL 826_ ESSAI 831_ GGQLM 836_ ASAAT 841_ ESPFA 846_ QSRRI 851_ DDSTV 856_ AGVAF 861_ ARYIL 866_ VGCWK 871_ NLIDT 876_ LSTPL 881_ TGRMA 886_ GSSKG 891_ LAFIL 896_ GAEGI 901_ KEQNQ 906_ KERDA 911_ ICMSL 916_ DGLRK 921_ AARLS 926_ CALGV 931_ AANCA 936_ SALAQ 941_ MAAAS 946_ CVQEE 951_ KEERE 956_ AQEPS 961_ DAITQ 966_ VKLKV 971_ EQKLE 976_ QIGKV 981_ QGVWL 986_ HTAHV 991_ LCMEA 996_ ILSVG 1001_ LEMGS 1006_ HNPDC 1011_ WPHVF 1016_ RVCEY 1021_ VGTLE 1026_ HNHFS 1031_ DGASQ 1036_ PPLTI 1041_ SQPQK 1046_ ATGSA 1051_ GLLGD 1056_ PECEG 1061_ SPPEH 1066_ SPEQG 1071_ RSLST 1076_ APVVQ 1081_ PLSIQ 1086_ DLVRE 1091_ GSRGR 1096_ ASDFR 1101_ GGSLM 1106_ SGSSA 1111_ AKVVL 1116_ TLSTQ 1121_ ADRLF 1126_ EDATD 1131_ KLNLM 1136_ ALGGF 1141_ LYQLK 1146_ KASQS 1151_ QLFHS 1156_ VTDTV 1161_ DYSLA 1166_ MPGEV 1171_ KSTQD 1176_ RKSAL 1181_ HLFRL 1186_ GNAML 1191_ RIVRS 1196_ KARPL 1201_ LHVMR 1206_ CWSLV 1211_ APHLV 1216_ EAACH 1221_ KERHV 1226_ SQKAV 1231_ SFIHD 1236_ ILTEV 1241_ LTDWN 1246_ EPPHF 1251_ HFNEA 1256_ LFRPF 1261_ ERIMQ 1266_ LELCD 1271_ EDVQD 1276_ QVVTS 1281_ IGELV 1286_ EVCST 1291_ QIQSG 1296_ WRPLF 1301_ SALET 1306_ VHGGN 1311_ KSEMK 1316_ EYLVG 1321_ DYSMG 1326_ KGQAP 1331_ VFDVF 1336_ EAFLN 1341_ TDNIQ 1346_ VFANA 1351_ ATSYI 1356_ MCLMK 1361_ FVKGL 1366_ GEVDC 1371_ KEIGD 1376_ CAPAP 1381_ GAPST 1386_ DLCLP 1391_ ALDYL 1396_ RRCSQ 1401_ LLAKI 1406_ YKMPL 1411_ KPIFL 1416_ SGRLA 1421_ GLPRR 1426_ LQEQS 1431_ ASSED 1436_ GIESV 1441_ LSDFD 1446_ DDTGL 1451_ IEVWI 1456_ ILLEQ 1461_ LTAAV 1466_ SNCPR 1471_ QHQPP 1476_ TLDLL 1481_ FELLR 1486_ DVTKT 1491_ PGPGF 1496_ GIYAV 1501_ VHLLL 1506_ PVMSV 1511_ WLRRS 1516_ HKDHS 1521_ YWDMA 1526_ SANFK 1531_ HAIGL 1536_ SCELV 1541_ VEHIQ 1546_ SFLHS 1551_ DIRYE 1556_ SMINT 1561_ MLKDL 1566_ FELLV 1571_ ACVAK 1576_ PTETI 1581_ SRVGC 1586_ SCIRY 1591_ VLVTA 1596_ GPVFT 1601_ EEMWR 1606_ LACCA 1611_ LQDAF 1616_ SATLK 1621_ PVKDL 1626_ LGCFH 1631_ SGTES 1636_ FSGEG 1641_ CQVRV 1646_ AAPSS 1651_ SPSAE 1656_ AEYWR 1661_ IRAMA 1666_ QQVFM 1671_ LDTQC 1676_ SPKTP 1681_ NNFDH 1686_ AQSCQ 1691_ LIIEL 1696_ PPDEK 1701_ PNGHT 1706_ KKSVS 1711_ FREIV 1716_ VSLLS 1721_ HQVLL 1726_ QNLYD 1731_ ILLEE 1736_ FVKGP 1741_ SPGEE 1746_ KTIQV 1751_ PEAKL 1756_ AGFLR 1761_ YISMQ 1766_ NLAVI 1771_ FDLLL 1776_ DSYRT 1781_ AREFD 1786_ TSPGL 1791_ KCLLK 1796_ KVSGI 1801_ GGAAN 1806_ LYRQS 1811_ AMSFN 1816_ IYFHA 1821_ LVCAV 1826_ LTNQE 1831_ TITAE 1836_ QVKKV 1841_ LFEDD 1846_ ERSTD 1851_ SSQQC 1856_ SSEDE 1861_ DIFEE 1866_ TAQVS 1871_ PPRGK 1876_ EKRQW 1881_ RARMP 1886_ LLSVQ 1891_ PVSNA 1896_ DWVWL 1901_ VKRLH 1906_ KLCME 1911_ LCNNY 1916_ IQMHL 1921_ DLENC 1926_ MEEPP 1931_ IFKGD 1936_ PFFIL 1941_ PSFQS 1946_ ESSTP 1951_ STGGF 1956_ SGKET 1961_ PSEDD 1966_ RSQSR 1971_ EHMGE 1976_ SLSLK 1981_ AGGGD 1986_ LLLPP 1991_ SPKVE 1996_ KKDPS 2001_ RKKEW 2006_ WENAG 2011_ NKIYT 2016_ MAADK 2021_ TISKL 2026_ MTEYK 2031_ KRKQQ 2036_ HNLSA 2041_ FPKEV 2046_ KVEKK 2051_ GEPLG 2056_ PRGQD 2061_ SPLLQ 2066_ RPQHL 2071_ MDQGQ 2076_ MRHSF 2081_ SAGPE 2086_ LLRQD 2091_ KRPRS 2096_ GSTGS 2101_ SLSVS 2106_ VRDAE 2111_ AQIQA 2116_ WTNMV 2121_ LTVLN 2126_ QIQIL 2131_ PDQTF 2136_ TALQP 2141_ AVFPC 2146_ ISQLT 2151_ CHVTD 2156_ IRVRQ 2161_ AVREW 2166_ LGRVG 2171_RVYDI
1: Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786)