Zinc finger protein 658
1_MNMSQ 6_ ASVSF 11_ QDVTV 16_ EFTRE 21_ EWQHL 26_ GPVER 31_ TLYRD 36_ VMLEN 41_ YSHLI 46_ SVGYC 51_ ITKPK 56_ VISKL 61_ EKGEE 66_ PWSLE 71_ DEFLN 76_ QRYPG 81_ YFKVD 86_ HIKGI 91_ REKQE 96_ KPLWQ 101_ EIFIS 106_ DADKT 111_ LSKEG 116_ QKVLE 121_ KPFNL 126_ EIAPE 131_ LSEKI 136_ SCKCD 141_ SHRMN 146_ LPVAS 151_ QLIIS 156_ ERKYS 161_ RKKTE 166_ YMNVC 171_ EKLQL 176_ DIKHE 181_ KAHAE 186_ EKSYE 191_ HGENA 196_ KAFSY 201_ KKDQH 206_ WKFQT 211_ LEESF 216_ ECDGS 221_ GQGLY 226_ DKTIC 231_ ITPQS 236_ FLTGE 241_ KSCKD 246_ DEFRK 251_ NFDKI 256_ TLFNH 261_ MRTDT 266_ RGKCS 271_ DLNEY 276_ GTSCD 281_ KTTAV 286_ EYNKV 291_ HMAMT 296_ HYECN 301_ ERGIN 306_ FSRKS 311_ PLTQS 316_ QRTIT 321_ GWSAF 326_ ESNKC 331_ EENFS 336_ QSSAH 341_ IVHQK 346_ TQAGD 351_ KFGEH 356_ NECTD 361_ ALYQK 366_ LDFTA 371_ HQRIH 376_ TEDKF 381_ YLSDE 386_ HGKCR 391_ KSFYR 396_ KAHLI 401_ QHQRP 406_ HSGEK 411_ TYQYE 416_ ECAKS 421_ FCSSS 426_ HPIQH 431_ PGTYV 436_ GFKLY 441_ ECNEC 446_ GKAFC 451_ QNSNL 456_ SKHLR 461_ IHTKE 466_ KPCDN 471_ NGCGR 476_ SYKSP 481_ LIGHQ 486_ KTDAE 491_ MELCG 496_ GSEYG 501_ KTSHL 506_ KGHQR 511_ ILMGE 516_ KPYEC 521_ IECGK 526_ TFSKT 531_ SHLRA 536_ HQRIH 541_ TGEKP 546_ YECVE 551_ CEKTF 556_ SHKTH 561_ LSVHQ 566_ RVHTG 571_ EKPYE 576_ CNDCG 581_ KSFTY 586_ NSALR 591_ AHQRI 596_ HTGEK 601_ PYECS 606_ DCEKT 611_ FAHNS 616_ ALRAH 621_ HRIHT 626_ GEKPY 631_ ECNEC 636_ GRSFA 641_ HISVL 646_ KAHQR 651_ IHTGE 656_ KPYEC 661_ NECGR 666_ SFTYN 671_ SALRA 676_ HQRIH 681_ TGRKP 686_ YECSD 691_ CEKTF 696_ AHNSA 701_ LKIHQ 706_ RIHTG 711_ EKPYE 716_ CNECE 721_ KTFAH 726_ NSALR 731_ AHQNI 736_ HTGEK 741_ LYECS 746_ ECGKT 751_ FFQKT 756_ RLSTH 761_ RRIHT 766_ GEKPY 771_ ECSKC 776_ GKTFS 781_ QKSYL 786_ SGHER 791_ IHTGE 796_ KPYEC 801_ NVCGK 806_ TFVYK 811_ AALIV 816_ HQRIH 821_ TGEKP 826_ YECNQ 831_ CGKTF 836_ SQRTH 841_ LCAHQ 846_ RIHTG 851_ EKPYE 856_ CNECG 861_ KTFAD 866_ NSALR 871_ AHHRI 876_ HTGEK 881_ PYECN 886_ DCGKT 891_ FSKTS 896_ HLRAH 901_ LRTRS 906_ GEKPY 911_ ECSEC 916_ GKTFS 921_ EKSYV 926_ SAHQR 931_ VHTGE 936_ KPYEC 941_ NVCGK 946_ PFAHN 951_ STLRV 956_ HQRIH 961_ TGEKS 966_ YECND 971_ CGKTF 976_ SQKSH 981_ LSAHQ 986_ RIHTG 991_ EKPYE 996_ CNECG 1001_ KAFAQ 1006_ NSTLR 1011_ VHQRI 1016_ HTGEK 1021_ PYECD 1026_ ECGKT 1031_ FVRKA 1036_ ALRVH 1041_ HTRMH 1046_ TREKT 1051_LACNG
1: Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply