Transmembrane protein 164
1_MSRYS 6_ YQSLL 11_ DWLYG 16_ GVDPS 21_ FAGNG 26_ GPDCA 31_ AFLSW 36_ QQRLL 41_ ESVVV 46_ LTLAL 51_ LEILV 56_ ALRHI 61_ LRQTK 66_ EDGRG 71_ SPGSQ 76_ PEQVT 81_ QRPEE 86_ GKESL 91_ SKNLL 96_ LVALC 101_ LTFGV 106_ EVGFK 111_ FATKT 116_ VIYLL 121_ NPCHL 126_ VTMMH 131_ IFLLA 136_ CPPCR 141_ GAIVV 146_ FKLQM 151_ HMLNG 156_ ALLAL 161_ LFPVV 166_ NTRLL 171_ PFELE 176_ IYYIQ 181_ HVMLY 186_ VVPIY 191_ LLWKG 196_ GAYTP 201_ EPLSS 206_ FRWAL 211_ LSTGL 216_ MFFYH 221_ FSVLQ 226_ ILGLV 231_ TEVNL 236_ NNMLC 241_ PAISD 246_ PFYGP 251_ WYRIW 256_ ASGHQ 261_ TLMTM 266_ THGKL 271_ VILFS 276_ YMAGP 281_ LCKYL 286_ LDLLR 291_LPAKK
1: Positive regulator of ferroptosis (PubMed:35947500, PubMed:36782012). Involved in the acylation of ether lysophospholipids with the arachidonoyl chain (5Z,8Z,11Z,14Z-eicosatetraenoyl; C20:4) of diacylglycerophospholipids, generating C20:4 ether glycerophospholipids (ePEs) such as 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine (PE (P-18:0/20:4)), which promotes ferroptosis (PubMed:36782012). Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death (PubMed:35947500)