RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C)
1_MPSGS 6_ SAALA 11_ LAAAP 16_ APLPQ 21_ PPPPP 26_ PPPPP 31_ PLPPP 36_ SGGPE 41_ LEGDG 46_ LLLRE 51_ RLAAL 56_ GLDDP 61_ SPAEP 66_ GAPAL 71_ RAPAA 76_ AAQGQ 81_ ARRAA 86_ ELSPE 91_ ERAPP 96_ GRPGA 101_ PEAAE 106_ LELEE 111_ DEEEG 116_ EEAEL 121_ DGDLL 126_ EEEEL 131_ EEAEE 136_ EDRSS 141_ LLLLS 146_ PPAAT 151_ ASQTQ 156_ QIPGG 161_ SLGSV 166_ LLPAA 171_ RFDAR 176_ EAAAA 181_ AAAAG 186_ VLYGG 191_ DDAQG 196_ MMAAM 201_ LSHAY 206_ GPGGC 211_ GAAAA 216_ ALNGE 221_ QAALL 226_ RRKSV 231_ NTTEC 236_ VPVPS 241_ SEHVA 246_ EIVGR 251_ QGCKI 256_ KALRA 261_ KTNTY 266_ IKTPV 271_ RGEEP 276_ IFVVT 281_ GRKED 286_ VAMAK 291_ REILS 296_ AAEHF 301_ SMIRA 306_ SRNKN 311_ GPALG 316_ GLSCS 321_ PNLPG 326_ QTTVQ 331_ VRVPY 336_ RVVGL 341_ VVGPK 346_ GATIK 351_ RIQQQ 356_ THTYI 361_ VTPSR 366_ DKEPV 371_ FEVTG 376_ MPENV 381_ DRARE 386_ EIEMH 391_ IAMRT 396_ GNYIE 401_ LNEEN 406_ DFHYN 411_ GTDVS 416_ FEGGT 421_ LGSAW 426_ LSSNP 431_ VPPSR 436_ ARMIS 441_ NYRND 446_ SSSSL 451_ GSGST 456_ DSYFG 461_ SNRLA 466_ DFSPT 471_ SPFST 476_ GNFWF 481_ GDTLP 486_ SVGSE 491_ DLAVD 496_ SPAFD 501_ SLPTS 506_ AQTIW 511_ TPFEP 516_ VNPLS 521_ GFGSD 526_ PSGNM 531_ KTQRR 536_ GSQPS 541_ TPRLS 546_ PTFPE 551_ SIEHP 556_ LARRV 561_ RSDPP 566_ STGNH 571_ VGLPI 576_ YIPAF 581_ SNGTN 586_ SYSSS 591_ NGGST 596_ SSSPP 601_ ESRRK 606_ HDCVI 611_ CFENE 616_ VIAAL 621_ VPCGH 626_ NLFCM 631_ ECANK 636_ ICEKR 641_ TPSCP 646_ VCQTA 651_VTQAI
1: E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation