Ras-interacting protein 1 (Rain)
1_MLSGE 6_ RKEGG 11_ SPRFG 16_ KLHLP 21_ VGLWI 26_ NSPRK 31_ QLAKL 36_ GRRWP 41_ SAASV 46_ KSSSS 51_ DTGSR 56_ SSEPL 61_ PPPPP 66_ HVELR 71_ RVGAV 76_ KAAGG 81_ ASGSR 86_ AKRIS 91_ QLFRG 96_ SGTGT 101_ TGSSG 106_ AGGPG 111_ TPGGA 116_ QRWAS 121_ EKKLP 126_ ELAAG 131_ VAPEP 136_ PLATR 141_ ATAPP 146_ GVLKI 151_ FGAGL 156_ ASGAN 161_ YKSVL 166_ ATARS 171_ TAREL 176_ VAEAL 181_ ERYGL 186_ AGSPG 191_ GGPGE 196_ SSCVD 201_ AFALC 206_ DALGR 211_ PAAAG 216_ VGSGE 221_ WRAEH 226_ LRVLG 231_ DSERP 236_ LLVQE 241_ LWRAR 246_ PGWAR 251_ RFELR 256_ GREEA 261_ RRLEQ 266_ EAFGA 271_ ADSEG 276_ TGAPS 281_ WRPQK 286_ NRSRA 291_ ASGGA 296_ ALASP 301_ GPGTG 306_ SGAPA 311_ GSGGK 316_ ERSEN 321_ LSLRR 326_ SVSEL 331_ SLQGR 336_ RRRQQ 341_ ERRQQ 346_ ALSMA 351_ PGAAD 356_ AQIGT 361_ ADPGD 366_ FDQLT 371_ QCLIQ 376_ APSNR 381_ PYFLL 386_ LQGYQ 391_ DAQDF 396_ VVYVM 401_ TREQH 406_ VFGRG 411_ GNSSG 416_ RGGSP 421_ APYVD 426_ TFLNA 431_ PDILP 436_ RHCTV 441_ RAGPE 446_ HPAMV 451_ RPSRG 456_ APVTH 461_ NGCLL 466_ LREAE 471_ LHPGD 476_ LLGLG 481_ EHFLF 486_ MYKDP 491_ RTGGS 496_ GPARP 501_ PWLPA 506_ RPGAT 511_ PPGPG 516_ WAFSC 521_ RLCGR 526_ GLQER 531_ GEALA 536_ AYLDG 541_ REPVL 546_ RFRPR 551_ EEEAL 556_ LGEIV 561_ RAAAA 566_ GSGDL 571_ PPLGP 576_ ATLLA 581_ LCVQH 586_ SAREL 591_ ELGHL 596_ PRLLG 601_ RLARL 606_ IKEAV 611_ WEKIK 616_ EIGDR 621_ QPENH 626_ PEGVP 631_ EVPLT 636_ PEAVS 641_ VELRP 646_ LMLWM 651_ ANTTE 656_ LLSFV 661_ QEKVL 666_ EMEKE 671_ ADQED 676_ PQLCN 681_ DLELC 686_ DEAMA 691_ LLDEV 696_ IMCTF 701_ QQSVY 706_ YLTKT 711_ LYSTL 716_ PALLD 721_ SNPFT 726_ AGAEL 731_ PGPGA 736_ ELGAM 741_ PPGLR 746_ PTLGV 751_ FQAAL 756_ ELTSQ 761_ CELHP 766_ DLVSQ 771_ TFGYL 776_ FFFSN 781_ ASLLN 786_ SLMER 791_ GQGRP 796_ FYQWS 801_ RAVQI 806_ RTNLD 811_ LVLDW 816_ LQGAG 821_ LGDIA 826_ TEFFR 831_ KLSMA 836_ VNLLC 841_ VPRTS 846_ LLKAS 851_ WSSLR 856_ TDHPT 861_ LTPAQ 866_ LHHLL 871_ SHYQL 876_ GPGRG 881_ PPAAW 886_ DPPPA 891_ EREAV 896_ DTGDI 901_ FESFS 906_ SHPPL 911_ ILPLG 916_ SSRLR 921_ LTGPV 926_ TDDAL 931_ HRELR 936_ RLRRL 941_ LWDLE 946_ QQELP 951_ ANYRH 956_GPPVA
1: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy