Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP)
1_MESSD 6_ VELDL 11_ QRSVQ 16_ AVLRE 21_ LSTQA 26_ PALQS 31_ NQGMW 36_ RWSLH 41_ KKVER 46_ DPGKS 51_ PVLVR 56_ ILLRE 61_ LEKAE 66_ SQDLR 71_ HVIIP 76_ LLHTV 81_ MYVLT 86_ KATGI 91_ TEELY 96_ QRIYA 101_ FCTRL 106_ LTLPT 111_ PYCTV 116_ ALDCA 121_ IRLKT 126_ EMAVP 131_ GTLYQ 136_ RMVIA 141_ EQNLT 146_ NELYP 151_ YQERV 156_ FLFVD 161_ PELVS 166_ ASVCS 171_ ALLLE 176_ IEAAQ 181_ AQQTP 186_ ETCMR 191_ HVVSH 196_ ALQAA 201_ LGEAC 206_ HAGAL 211_ HRKLQ 216_ ASPRR 221_ TLEHY 226_ FHAVV 231_ AALEQ 236_ MASEA 241_ SPSRE 246_ GHVER 251_ LEEIY 256_ CSLLG 261_ PAAGR 266_ CGGDL 271_ VQERP 276_ PSIPL 281_ PSPYI 286_ TFHLW 291_ TGEEQ 296_ LWKEL 301_ VLFLR 306_ PRSQL 311_ RLSAD 316_ LEVLD 321_ LQGLR 326_ PDREL 331_ ARVSV 336_ LSTDS 341_ GIERD 346_ LPTGA 351_ DELPA 356_ PGSPE 361_ MERAG 366_ LQRKG 371_ GIKKR 376_ AWPLD 381_ FLMPG 386_ SWDGP 391_ PGLHR 396_ RTGRP 401_ SGDGE 406_ MLPGV 411_ SRLHT 416_ ARVLV 421_ LGDDR 426_ MLGRL 431_ AQAYH 436_ RLRKR 441_ ETQKF 446_ CLTPR 451_ LSLQL 456_ YYIPV 461_ LAPEK 466_ PAASR 471_ QPELG 476_ ELATF 481_ LGRVD 486_ PWYQS 491_ NVNTL 496_ CPAIH 501_ KLAEM 506_ PPSLD 511_ TSRTV 516_ DPFIL 521_ DVITY 526_ YIRMG 531_ TQPIY 536_ FQIYT 541_ VKIFF 546_ SDLSQ 551_ DPTED 556_ IFLIE 561_ LKVKI 566_ QDSKF 571_ PKDGF 576_ SPRRR 581_ GVAEG 586_ PGAEL 591_ SLCYQ 596_ KALLS 601_ HRPRE 606_ VTVSL 611_ RATGL 616_ ILKAI 621_ PASDT 626_ EVSGS 631_ SHCPL 636_ PAAPV 641_ TDHTC 646_ LNVNV 651_ TEVVK 656_ SSNLA 661_ GKSFS 666_ TVTNT 671_ FRTNN 676_ IQIQS 681_ RDQRL 686_ LTLSL 691_ DKDDQ 696_ RTFRD 701_ VVRFE 706_ VAPCP 711_ EPCSG 716_ AQKSK 721_ APWLN 726_ LHGQQ 731_ EVEAI 736_ KAKPK 741_ PLLMP 746_INTFS
1: Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS