Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)
1_MTARG 6_ QSPLA 11_ PLLET 16_ LEDPS 21_ ASHGG 26_ QTDAY 31_ LTLTS 36_ RMTGE 41_ EGKEV 46_ ITEIE 51_ KKLPR 56_ LYKVL 61_ KTHIS 66_ SQNSE 71_ LSSAA 76_ LQALG 81_ FCLYN 86_ PKITS 91_ ELSEA 96_ NALEL 101_ LSKLN 106_ DTIKN 111_ SDKNV 116_ RTRAL 121_ WVISK 126_ QTFPS 131_ EVVGK 136_ MVSSI 141_ IDSLE 146_ ILFNK 151_ GETHS 156_ AVVDF 161_ EALNV 166_ IVRLI 171_ EQAPI 176_ QMGEE 181_ AVRWA 186_ KLVIP 191_ LVVHS 196_ AQKVH 201_ LRGAT 206_ ALEMG 211_ MPLLL 216_ QKQQE 221_ IASIT 226_ EQLMT 231_ TKLIS 236_ ELQKL 241_ FMSKN 246_ ETYVL 251_ KLWPL 256_ FVKLL 261_ GRTLH 266_ RSGSF 271_ INSLL 276_ QLEEL 281_ GFRSG 286_ APMIK 291_ KIAFI 296_ AWKSL 301_ IDNFA 306_ LNPDI 311_ LCSAK 316_ RLKLL 321_ MQPLS 326_ SIHVR 331_ TETLA 336_ LTKLE 341_ VWWYL 346_ LMRLG 351_ PHLPA 356_ NFEQV 361_ CVPLI 366_ QSTIS 371_ IDSNA 376_ SPQGN 381_ SCHVA 386_ TSPGL 391_ NPMTP 396_ VHKGA 401_ SSPYG 406_ APGTP 411_ RMNLS 416_ SNLGG 421_ MATIP 426_ SIQLL 431_ GLEML 436_ LHFLL 441_ GPEAL 446_ SFAKQ 451_ NKLVL 456_ SLEPL 461_ EHPLI 466_ SSPSF 471_ FSKHA 476_ NTLIT 481_ AVHDS 486_ FVAVG 491_ KDAPD 496_ VVVSA 501_ IWKEL 506_ ISLVK 511_ SVTES 516_ GNKKE 521_ KPGSE 526_ VLTLL 531_ LKSLE 536_ SIVKS 541_ EVFPV 546_ SKTLV 551_ LMEIT 556_ IKGLP 561_ QKVLG 566_ SPAYQ 571_ VANMD 576_ ILNGT 581_ PALFL 586_ IQLIF 591_ NNFLE 596_ CGVSD 601_ ERFFL 606_ SLESL 611_ VGCVL 616_ SGPTS 621_ PLAFS 626_ DSVLN 631_ VINQN 636_ AKQLE 641_ NKEHL 646_ WKMWS 651_ VIVTP 656_ LTELI 661_ NQTNE 666_ VNQGD 671_ ALEHN 676_ FSAIY 681_ GALTL 686_ PVNHI 691_ FSEQR 696_ FPVAT 701_ MKTLL 706_ RTWSE 711_ LYRAF 716_ ARCAA 721_ LVATA 726_ EENLC 731_ CEELS 736_ SKIMS 741_ SLEDE 746_ GFSNL 751_ LFVDR 756_ IIYII 761_ TVMVD 766_ CIDFS 771_ PYNIK 776_ YQPKV 781_ KSPQR 786_ PSDWS 791_ KKKNE 796_ PLGKL 801_ TSLFK 806_ LIVKV 811_ IYSFH 816_ TLSFK 821_ EAHSD 826_ TLFTI 831_ GNSIT 836_ GIISS 841_ VLGHI 846_ SLPSM 851_ IRKIF 856_ ATLTR 861_ PLALF 866_ YENSK 871_ LDEVP 876_ KVYSC 881_ LNNKL 886_ EKLLG 891_ EIIAC 896_ LQFSY 901_ TGTYD 906_ SELLE 911_ QLSPL 916_ LCIIF 921_ LHKNK 926_ QIRKQ 931_ SAQFW 936_ NATFA 941_ KVMML 946_ VYPEE 951_ LKPVL 956_ TQAKQ 961_ KFLLL 966_ LPGLE 971_ TVEMM 976_ EESSG 981_ PYSDG 986_ TENSQ 991_ LNVKI 996_ SGMER 1001_ KSNGK 1006_ RDSFL 1011_ AQTKN 1016_ KKENM 1021_ KPAAK 1026_ LKLES 1031_ SSLKV 1036_ KGEIL 1041_ LEEEK 1046_ STDFV 1051_ FIPPE 1056_ GKDAK 1061_ ERILT 1066_ DHQKE 1071_ VLKTK 1076_ RCDIP 1081_ AMYNN 1086_ LDVSQ 1091_ DTLFT 1096_ QYSQE 1101_ EPMEI 1106_ PTLTR 1111_ KPKED 1116_ SKMMI 1121_ TEEQM 1126_ DSDIV 1131_ IPQDV 1136_ TEDCG 1141_ MAEHL 1146_ EKSSL 1151_ SNNEC 1156_ GSLDK 1161_ TSPEM 1166_ SNSNN 1171_ DERKK 1176_ ALISS 1181_ RKTST 1186_ ECASS 1191_ TENSF 1196_ VVSSS 1201_ SVSNT 1206_ TVAGT 1211_ PPYPT 1216_ SRRQT 1221_ FITLE 1226_ KFDGS 1231_ ENRPF 1236_ SPSPL 1241_ NNISS 1246_ TVTVK 1251_ NNQET 1256_ MIKTD 1261_ FLPKA 1266_ KQREG 1271_ TFSKS 1276_ DSEKI 1281_ VNGTK 1286_ RSSRR 1291_ AGKAE 1296_ QTGNK 1301_ RSKPL 1306_ MRSEP 1311_ EKNTE 1316_ ESVEG 1321_ IVVLE 1326_ NNPPG 1331_ LLNQT 1336_ ECVSD 1341_ NQVHL 1346_ SESTM 1351_ EHDNT 1356_ KLKAA 1361_ TVENA 1366_ VLLET 1371_ NTVEE 1376_ KNVEI 1381_ NLESK 1386_ ENTPP 1391_ VVISA 1396_ DQMVN 1401_ EDSQV 1406_ QITPN 1411_ QKTLR 1416_ RSSRR 1421_ RSEVV 1426_ ESTTE 1431_ SQDKE 1436_ NSHQK 1441_ KERRK 1446_ EEEKP 1451_ LQKSP 1456_ LHIKD 1461_ DVLPK 1466_ QKLIA 1471_ EQTLQ 1476_ ENLIE 1481_ KGSNL 1486_ HEKTL 1491_ GETSA 1496_ NAETE 1501_ QNKKK 1506_ ADPEN 1511_ IKSEG 1516_ DGTQD 1521_ IVDKS 1526_ SEKLV 1531_ RGRTR 1536_ YQTRR 1541_ ASQGL 1546_ LSSIE 1551_ NSESD 1556_ SSEAK 1561_ EEGSR 1566_ KKRSG 1571_ KWKNK 1576_ SNESV 1581_ DIQDQ 1586_ EEKVV 1591_ KQECI 1596_ KAENQ 1601_ SHDYK 1606_ ATSEE 1611_ DVSIK 1616_ SPICE 1621_ KQDES 1626_ NTVIC 1631_ QDSTV 1636_ TSDLL 1641_ QVPDD 1646_ LPNVC 1651_ EEKNE 1656_ TSKYA 1661_ EYSFT 1666_ SLPVP 1671_ ESNLR 1676_ TRNAI 1681_ KRLHK 1686_ RDSFD 1691_ NCSLG 1696_ ESSKI 1701_ GISDI 1706_ SSLSE 1711_ KTFQT 1716_ LECQH 1721_ KRSRR 1726_ VRRSK 1731_ GCDCC 1736_ GEKSQ 1741_ PQEKS 1746_ LIGLK 1751_ NTENN 1756_ DVEIS 1761_ ETKKA 1766_ DVQAP 1771_ VSPSE 1776_ TSQAN 1781_ PYSEG 1786_ QFLDE 1791_ HHSVN 1796_ FHLGL 1801_ KEDND 1806_ TINDS 1811_ LIVSE 1816_ TKSKE 1821_ NTMQE 1826_ SLPSG 1831_ IVNFR 1836_ EEICD 1841_ MDSSE 1846_ AMSLE 1851_ SQESP 1856_ NENFK 1861_ TVGPC 1866_ LGDSK 1871_ NVSQE 1876_ SLETK 1881_ EEKPE 1886_ ETPKM 1891_ ELSLE 1896_ NVTVE 1901_ GNACK 1906_ VTESN 1911_ LEKAK 1916_ TMELN 1921_ VGNEA 1926_ SFHGQ 1931_ ERTKT 1936_ GISEE 1941_ AAIEE 1946_ NKRND 1951_ DSEAD 1956_ TAKLN 1961_ AKEVA 1966_ TEEFN 1971_ SDISL 1976_ SDNTT 1981_ PVKLN 1986_ AQTEI 1991_ SEQTA 1996_ AGELD 2001_ GGNDV 2006_ SDLHS 2011_ SEETN 2016_ TKMKN 2021_ NEEMM 2026_ IGEAM 2031_ AETGH 2036_ DGETE 2041_ NEGIT 2046_ TKTSK 2051_ PDEAE 2056_ TNMLT 2061_ AEMDN 2066_ FVCDT 2071_ VEMST 2076_ EEGII 2081_ DANKT 2086_ ETNTE 2091_ YSKSE 2096_ EKLDN 2101_ NQMVM 2106_ ESDIL 2111_ QEDHH 2116_ TSQKV 2121_ EEPSQ 2126_ CLASG 2131_ TAISE 2136_ LIIED 2141_ NNASP 2146_ QKLRE 2151_ LDPSL 2156_ VSAND 2161_ SPSGM 2166_ QTRCV 2171_ WSPLA 2176_ SPSTS 2181_ ILKRG 2186_ LKRSQ 2191_ EDEIS 2196_ SPVNK 2201_ VRRVS 2206_ FADPI 2211_ YQAGL 2216_ ADDID 2221_ RRCSI 2226_ VRSHS 2231_ SNSSP 2236_ IGKSV 2241_ KTSPT 2246_ TQSKH 2251_ NTTSA 2256_ KGFLS 2261_ PGSRS 2266_ PKFKS 2271_ SKKCL 2276_ ISEMA 2281_ KESIP 2286_ CPTES 2291_ VYPPL 2296_ VNCVA 2301_ PVDII 2306_ LPQIT 2311_ SNMWA 2316_ RGLGQ 2321_ LIRAK 2326_ NIKTI 2331_ GDLST 2336_ LTASE 2341_ IKTLP 2346_ IRSPK 2351_ VSNVK 2356_ KALRI 2361_ YHEQQ 2366_ VKTRG 2371_ LEEIP 2376_ VFDIS 2381_ EKTVN 2386_ GIENK 2391_ SLSPD 2396_ EERLV 2401_ SDIID 2406_ PVALE 2411_ IPLSK 2416_ NLLAQ 2421_ ISALA 2426_ LQLDS 2431_ EDLHN 2436_ YSGSQ 2441_ LFEMH 2446_ EKLSC 2451_ MANSV 2456_ IKNLQ 2461_ SRWRS 2466_PSHEN
1: Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity)