Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
1_MSGEV 6_ RLRQL 11_ EQFIL 16_ DGPAQ 21_ TNGQC 26_ FSVET 31_ LLDIL 36_ ICLYD 41_ ECNNS 46_ PLRRE 51_ KNILE 56_ YLEWA 61_ KPFTS 66_ KVKQM 71_ RLHRE 76_ DFEIL 81_ KVIGR 86_ GAFGE 91_ VAVVK 96_ LKNAD 101_ KVFAM 106_ KILNK 111_ WEMLK 116_ RAETA 121_ CFREE 126_ RDVLV 131_ NGDNK 136_ WITTL 141_ HYAFQ 146_ DDNNL 151_ YLVMD 156_ YYVGG 161_ DLLTL 166_ LSKFE 171_ DRLPE 176_ DMARF 181_ YLAEM 186_ VIAID 191_ SVHQL 196_ HYVHR 201_ DIKPD 206_ NILMD 211_ MNGHI 216_ RLADF 221_ GSCLK 226_ LMEDG 231_ TVQSS 236_ VAVGT 241_ PDYIS 246_ PEILQ 251_ AMEDG 256_ KGRYG 261_ PECDW 266_ WSLGV 271_ CMYEM 276_ LYGET 281_ PFYAE 286_ SLVET 291_ YGKIM 296_ NHKER 301_ FQFPA 306_ QVTDV 311_ SENAK 316_ DLIRR 321_ LICSR 326_ EHRLG 331_ QNGIE 336_ DFKKH 341_ PFFSG 346_ IDWDN 351_ IRNCE 356_ APYIP 361_ EVSSP 366_ TDTSN 371_ FDVDD 376_ DCLKN 381_ SETMP 386_ PPTHT 391_ AFSGH 396_ HLPFV 401_ GFTYT 406_ SSCVL 411_ SDRSC 416_ LRVTA 421_ GPTSL 426_ DLDVN 431_ VQRTL 436_ DNNLA 441_ TEAYE 446_ RRIKR 451_ LEQEK 456_ LELSR 461_ KLQES 466_ TQTVQ 471_ ALQYS 476_ TVDGP 481_ LTASK 486_ DLEIK 491_ NLKEE 496_ IEKLR 501_ KQVTE 506_ SSHLE 511_ QQLEE 516_ ANAVR 521_ QELDD 526_ AFRQI 531_ KAYEK 536_ QIKTL 541_ QQERE 546_ DLNKE 551_ LVQAS 556_ ERLKN 561_ QSKEL 566_ KDAHC 571_ QRKLA 576_ MQEFM 581_ EINER 586_ LTELH 591_ TQKQK 596_ LARHV 601_ RDKEE 606_ EVDLV 611_ MQKVE 616_ SLRQE 621_ LRRTE 626_ RAKKE 631_ LEVHT 636_ EALAA 641_ EASKD 646_ RKLRE 651_ QSEHY 656_ SKQLE 661_ NELEG 666_ LKQKQ 671_ ISYSP 676_ GVCSI 681_ EHQQE 686_ ITKLK 691_ TDLEK 696_ KSIFY 701_ EEELS 706_ KREGI 711_ HANEI 716_ KNLKK 721_ ELHDS 726_ EGQQL 731_ ALNKE 736_ IMILK 741_ DKLEK 746_ TRRES 751_ QSERE 756_ EFESE 761_ FKQQY 766_ EREKV 771_ LLTEE 776_ NKKLT 781_ SELDK 786_ LTTLY 791_ ENLSI 796_ HNQQL 801_ EEEVK 806_ DLADK 811_ KESVA 816_ HWEAQ 821_ ITEII 826_ QWVSD 831_ EKDAR 836_ GYLQA 841_ LASKM 846_ TEELE 851_ ALRNS 856_ SLGTR 861_ ATDMP 866_ WKMRR 871_ FAKLD 876_ MSARL 881_ ELQSA 886_ LDAEI 891_ RAKQA 896_ IQEEL 901_ NKVKA 906_ SNIIT 911_ ECKLK 916_ DSEKK 921_ NLELL 926_ SEIEQ 931_ LIKDT 936_ EELRS 941_ EKGIE 946_ HQDSQ 951_ HSFLA 956_ FLNTP 961_ TDALD 966_ QFERS 971_ PSCTP 976_ ASKGR 981_ RTVDS 986_ TPLSV 991_ HTPTL 996_ RKKGC 1001_ PGSTG 1006_ FPPKR 1011_ KTHQF 1016_ FVKSF 1021_ TTPTK 1026_ CHQCT 1031_ SLMVG 1036_ LIRQG 1041_ CSCEV 1046_ CGFSC 1051_ HITCV 1056_ NKAPT 1061_ TCPVP 1066_ PEQTK 1071_ GPLGI 1076_ DPQKG 1081_ IGTAY 1086_ EGHVR 1091_ IPKPA 1096_ GVKKG 1101_ WQRAL 1106_ AIVCD 1111_ FKLFL 1116_ YDIAE 1121_ GKASQ 1126_ PSVVI 1131_ SQVID 1136_ MRDEE 1141_ FSVSS 1146_ VLASD 1151_ VIHAS 1156_ RKDIP 1161_ CIFRV 1166_ TASQL 1171_ SASNN 1176_ KCSIL 1181_ MLADT 1186_ ENEKN 1191_ KWVGV 1196_ LSELH 1201_ KILKK 1206_ NKFRD 1211_ RSVYV 1216_ PKEAY 1221_ DSTLP 1226_ LIKTT 1231_ QAAAI 1236_ IDHER 1241_ IALGN 1246_ EEGLF 1251_ VVHVT 1256_ KDEII 1261_ RVGDN 1266_ KKIHQ 1271_ IELIP 1276_ NDQLV 1281_ AVISG 1286_ RNRHV 1291_ RLFPM 1296_ SALDG 1301_ RETDF 1306_ YKLSE 1311_ TKGCQ 1316_ TVTSG 1321_ KVRHG 1326_ ALTCL 1331_ CVAMK 1336_ RQVLC 1341_ YELFQ 1346_ SKTRH 1351_ RKFKE 1356_ IQVPY 1361_ NVQWM 1366_ AIFSE 1371_ QLCVG 1376_ FQSGF 1381_ LRYPL 1386_ NGEGN 1391_ PYSML 1396_ HSNDH 1401_ TLSFI 1406_ AHQPM 1411_ DAICA 1416_ VEISS 1421_ KEYLL 1426_ CFNSI 1431_ GIYTD 1436_ CQGRR 1441_ SRQQE 1446_ LMWPA 1451_ NPSSC 1456_ CYNAP 1461_ YLSVY 1466_ SENAV 1471_ DIFDV 1476_ NSMEW 1481_ IQTLP 1486_ LKKVR 1491_ PLNNE 1496_ GSLNL 1501_ LGLET 1506_ IRLIY 1511_ FKNKM 1516_ AEGDE 1521_ LVVPE 1526_ TSDNS 1531_ RKQMV 1536_ RNINN 1541_ KRRYS 1546_ FRVPE 1551_ EERMQ 1556_ QRREM 1561_ LRDPE 1566_ MRNKL 1571_ ISNPT 1576_ NFNHI 1581_ AHMGP 1586_ GDGIQ 1591_ ILKDL 1596_ PMNPR 1601_ PQESR 1606_ TVFSG 1611_ SVSIP 1616_ SITKS 1621_ RPEPG 1626_ RSMSA 1631_ SSGLS 1636_ ARSSA 1641_ QNGSA 1646_ LKREF 1651_ SGGSY 1656_ SAKRQ 1661_ PMPSP 1666_ SEGSL 1671_ SSGGM 1676_ DQGSD 1681_ APARD 1686_ FDGED 1691_ SDSPR 1696_ HSTAS 1701_ NSSNL 1706_ SSPPS 1711_ PASPR 1716_ KTKSL 1721_ SLEST 1726_DRGSW
1: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624)