Zinc finger protein Gfi-1b (Growth factor independent protein 1B) (Potential regulator of CDKN1A translocated in CML)
1_MPRSF 6_ LVKSK 11_ KAHTY 16_ HQPRV 21_ QEDEP 26_ LWPPA 31_ LTPVP 36_ RDQAP 41_ SNSPV 46_ LSTLF 51_ PNQCL 56_ DWTNL 61_ KREPE 66_ LEQDQ 71_ NLARM 76_ APAPE 81_ GPIVL 86_ SRPQD 91_ GDSPL 96_ SDSPP 101_ FYKPS 106_ FSWDT 111_ LATTY 116_ GHSYR 121_ QAPST 126_ MQSAF 131_ LEHSV 136_ SLYGS 141_ PLVPS 146_ TEPAL 151_ DFSLR 156_ YSPGM 161_ DAYHC 166_ VKCNK 171_ VFSTP 176_ HGLEV 181_ HVRRS 186_ HSGTR 191_ PFACD 196_ ICGKT 201_ FGHAV 206_ SLEQH 211_ THVHS 216_ QERSF 221_ ECRMC 226_ GKAFK 231_ RSSTL 236_ STHLL 241_ IHSDT 246_ RPYPC 251_ QFCGK 256_ RFHQK 261_ SDMKK 266_ HTYIH 271_ TGEKP 276_ HKCQV 281_ CGKAF 286_ SQSSN 291_ LITHS 296_ RKHTG 301_ FKPFS 306_ CELCT 311_ KGFQR 316_ KVDLR 321_RHRES
1: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation