E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
1_MSGIG 6_ NKRAA 11_ GEPGT 16_ SMPPE 21_ KKAAV 26_ EDSGT 31_ TVETI 36_ KLGGV 41_ SSTEE 46_ LDIRT 51_ LQTKN 56_ RKLAE 61_ MLDQR 66_ QAIED 71_ ELREH 76_ IEKLE 81_ RRQAT 86_ DDASL 91_ LIVNR 96_ YWSQF 101_ DENIR 106_ IILKR 111_ YDLEQ 116_ GLGDL 121_ LTERK 126_ ALVVP 131_ EPEPD 136_ SDSNQ 141_ ERKDD 146_ RERGE 151_ GQEPA 156_ FSFLA 161_ TLASS 166_ SSEEM 171_ ESQLQ 176_ ERVES 181_ SRRAV 186_ SQIVT 191_ VYDKL 196_ QEKVE 201_ LLSRK 206_ LNSGD 211_ NLIVE 216_ EAVQE 221_ LNSFL 226_ AQENM 231_ RLQEL 236_ TDLLQ 241_ EKHRT 246_ MSQEF 251_ SKLQS 256_ KVETA 261_ ESRVS 266_ VLESM 271_ IDDLQ 276_ WDIDK 281_ IRKRE 286_ QRLNR 291_ HLAEV 296_ LERVN 301_ SKGYK 306_ VYGAG 311_ SSLYG 316_ GTITI 321_ NARKF 326_ EEMNA 331_ ELEEN 336_ KELAQ 341_ NRLCE 346_ LEKLR 351_ QDFEE 356_ VTTQN 361_ EKLKV 366_ ELRSA 371_ VEQVV 376_ KETPE 381_ YRCMQ 386_ SQFSV 391_ LYNES 396_ LQLKA 401_ HLDEA 406_ RTLLH 411_ GTRGT 416_ HQHQV 421_ ELIER 426_ DEVSL 431_ HKKLR 436_ TEVIQ 441_ LEDTL 446_ AQVRK 451_ EYEML 456_ RIEFE 461_ QTLAA 466_ NEQAG 471_ PINRE 476_ MRHLI 481_ SSLQN 486_ HNHQL 491_ KGEVL 496_ RYKRK 501_ LREAQ 506_ SDLNK 511_ TRLRS 516_ GSALL 521_ QSQSS 526_ TEDPK 531_ DEPAE 536_ LKPDS 541_ EDLSS 546_ QSSAS 551_ KASQE 556_ DANEI 561_ KSKRD 566_ EEERE 571_ RERRE 576_ KERER 581_ ERERE 586_ KEKER 591_ EREKQ 596_ KLKES 601_ EKERD 606_ SAKDK 611_ EKGKH 616_ DDGRK 621_ KEAEI 626_ IKQLK 631_ IELKK 636_ AQESQ 641_ KEMKL 646_ LLDMY 651_ RSAPK 656_ EQRDK 661_ VQLMA 666_ AEKKS 671_ KAELE 676_ DLRQR 681_ LKDLE 686_ DKEKK 691_ ENKKM 696_ ADEDA 701_ LRKIR 706_ AVEEQ 711_ IEYLQ 716_ KKLAM 721_ AKQEE 726_ EALLS 731_ EMDVT 736_ GQAFE 741_ DMQEQ 746_ NIRLM 751_ QQLRE 756_ KDDAN 761_ FKLMS 766_ ERIKS 771_ NQIHK 776_ LLKEE 781_ KEELA 786_ DQVLT 791_ LKTQV 796_ DAQLQ 801_ VVRKL 806_ EEKEH 811_ LLQSN 816_ IGTGE 821_ KELGL 826_ RTQAL 831_ EMNKR 836_ KAMEA 841_ AQLAD 846_ DLKAQ 851_ LELAQ 856_ KKLHD 861_ FQDEI 866_ VENSV 871_ TKEKD 876_ MFNFK 881_ RAQED 886_ ISRLR 891_ RKLET 896_ TKKPD 901_ NVPKC 906_ DEILM 911_ EEIKD 916_ YKARL 921_ TCPCC 926_ NMRKK 931_ DAVLT 936_ KCFHV 941_ FCFEC 946_ VKTRY 951_ DTRQR 956_ KCPKC 961_ NAAFG 966_ANDFH
1: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation
2: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50