Protein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) (Hedgehog acyltransferase) (Melanoma antigen recognized by T-cells 2) (MART-2) (Skinny hedgehog protein 1)
1_MLPRW 6_ ELALY 11_ LLASL 16_ GFHFY 21_ SFYEV 26_ YKVSR 31_ EHEEE 36_ LDQEF 41_ ELETD 46_ TLFGG 51_ LKKDA 56_ TDFEW 61_ SFWME 66_ WGKQW 71_ LVWLL 76_ LGHMV 81_ VSQMA 86_ TLLAR 91_ KHRPW 96_ ILMLY 101_ GMWAC 106_ WCVLG 111_ TPGVA 116_ MVLLH 121_ TTISF 126_ CVAQF 131_ RSQLL 136_ TWLCS 141_ LLLLS 146_ TLRLQ 151_ GVEEV 156_ KRRWY 161_ KTENE 166_ YYLLQ 171_ FTLTV 176_ RCLYY 181_ TSFSL 186_ ELCWQ 191_ QLPAA 196_ STSYS 201_ FPWML 206_ AYVFY 211_ YPVLH 216_ NGPIL 221_ SFSEF 226_ IKQMQ 231_ QQEHD 236_ SLKAS 241_ LCVLA 246_ LGLGR 251_ LLCWW 256_ WLAEL 261_ MAHLM 266_ YMHAI 271_ YSSIP 276_ LLETV 281_ SCWTL 286_ GGLAL 291_ AQVLF 296_ FYVKY 301_ LVLFG 306_ VPALL 311_ MRLDG 316_ LTPPA 321_ LPRCV 326_ STMFS 331_ FTGMW 336_ RYFDV 341_ GLHNF 346_ LIRYV 351_ YIPVG 356_ GSQHG 361_ LLGTL 366_ FSTAM 371_ TFAFV 376_ SYWHG 381_ GYDYL 386_ WCWAA 391_ LNWLG 396_ VTVEN 401_ GVRRL 406_ VETPC 411_ IQDSL 416_ ARYFS 421_ PQARR 426_ RFHAA 431_ LASCS 436_ TSMLI 441_ LSNLV 446_ FLGGN 451_ EVGKT 456_ YWNRI 461_ FIQGW 466_ PWVTL 471_ SVLGF 476_ LYCYS 481_ HVGIA 486_WAQTY
1: Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling (PubMed:18534984, PubMed:24784881, PubMed:31875564). It also catalyzes N-terminal palmitoylation of DHH (PubMed:24784881). Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where SHH palmitoylation occurs (PubMed:31875564). It is an essential factor for proper embryonic development and testicular organogenesis (PubMed:24784881)