Gene name: PDE4DIP

Uniprot entry:

Q5VU43

Protein names:

Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein)

Protein sequence:

1_MSNGY 6_ RTLSQ 11_ HLNDL 16_ KKENF 21_ SLKLR 26_ IYFLE 31_ ERMQQ 36_ KYEAS 41_ REDIY 46_ KRNIE 51_ LKVEV 56_ ESLKR 61_ ELQDK 66_ KQHLD 71_ KTWAD 76_ VENLN 81_ SQNEA 86_ ELRRQ 91_ FEERQ 96_ QETEH 101_ VYELL 106_ ENKIQ 111_ LLQEE 116_ SRLAK 121_ NEAAR 126_ MAALV 131_ EAEKE 136_ CNLEL 141_ SEKLK 146_ GVTKN 151_ WEDVP 156_ GDQVK 161_ PDQYT 166_ EALAQ 171_ RDKRI 176_ EELNQ 181_ SLAAQ 186_ ERLVE 191_ QLSRE 196_ KQQLL 201_ HLLEE 206_ PTSME 211_ VQPMT 216_ EELLK 221_ QQKLN 226_ SHETT 231_ ITQQS 236_ VSDSH 241_ LAELQ 246_ EKIQQ 251_ TEATN 256_ KILQE 261_ KLNEM 266_ SYELK 271_ CAQES 276_ SQKQD 281_ GTIQN 286_ LKETL 291_ KSRER 296_ ETEEL 301_ YQVIE 306_ GQNDT 311_ MAKLR 316_ EMLHQ 321_ SQLGQ 326_ LHSSE 331_ GTSPA 336_ QQQVA 341_ LLDLQ 346_ SALFC 351_ SQLEI 356_ QKLQR 361_ VVRQK 366_ ERQLA 371_ DAKQC 376_ VQFVE 381_ AAAHE 386_ SEQQK 391_ EASWK 396_ HNQEL 401_ RKALQ 406_ QLQEE 411_ LQNKS 416_ QQLRA 421_ WEAEK 426_ YNEIR 431_ TQEQN 436_ IQHLN 441_ HSLSH 446_ KEQLL 451_ QEFRE 456_ LLQYR 461_ DNSDK 466_ TLEAN 471_ EMLLE 476_ KLRQR 481_ IHDKA 486_ VALER 491_ AIDEK 496_ FSALE 501_ EKEKE 506_ LRQLR 511_ LAVRE 516_ RDHDL 521_ ERLRD 526_ VLSSN 531_ EATMQ 536_ SMESL 541_ LRAKG 546_ LEVEQ 551_ LSTTC 556_ QNLQW 561_ LKEEM 566_ ETKFS 571_ RWQKE 576_ QESII 581_ QQLQT 586_ SLHDR 591_ NKEVE 596_ DLSAT 601_ LLCKL 606_ GPGQS 611_ EIAEE 616_ LCQRL 621_ QRKER 626_ MLQDL 631_ LSDRN 636_ KQVLE 641_ HEMEI 646_ QGLLQ 651_ SVSTR 656_ EQESQ 661_ AAAEK 666_ LVQAL 671_ MERNS 676_ ELQAL 681_ RQYLG 686_ GRDSL 691_ MSQAP 696_ ISNQQ 701_ AEVTP 706_ TGRLG 711_ KQTDQ 716_ GSMQI 721_ PSRDD 726_ STSLT 731_ AKEDV 736_ SIPRS 741_ TLGDL 746_ DTVAG 751_ LEKEL 756_ SNAKE 761_ ELELM 766_ AKKER 771_ ESQME 776_ LSALQ 781_ SMMAV 786_ QEEEL 791_ QVQAA 796_ DMESL 801_ TRNIQ 806_ IKEDL 811_ IKDLQ 816_ MQLVD 821_ PEDIP 826_ AMERL 831_ TQEVL 836_ LLREK 841_ VASVE 846_ SQGQE 851_ ISGNR 856_ RQQLL 861_ LMLEG 866_ LVDER 871_ SRLNE 876_ ALQAE 881_ RQLYS 886_ SLVKF 891_ HAHPE 896_ SSERD 901_ RTLQV 906_ ELEGA 911_ QVLRS 916_ RLEEV 921_ LGRSL 926_ ERLNR 931_ LETLA 936_ AIGGA 941_ AAGDD 946_ TEDTS 951_ TEFTD 956_ SIEEE 961_ AAHHS 966_ HQQLV 971_ KVALE 976_ KSLAT 981_ VETQN 986_ PSFSP 991_ PSPMG 996_ GDSNR 1001_ CLQEE 1006_ MLHLR 1011_ AEFHQ 1016_ HLEEK 1021_ RKAEE 1026_ ELKEL 1031_ KAQIE 1036_ EAGFS 1041_ SVSHI 1046_ RNTML 1051_ SLCLE 1056_ NAELK 1061_ EQMGE 1066_ AMSDG 1071_ WEIEE 1076_ DKEKG 1081_ EVMVE 1086_ TVVTK 1091_ EGLSE 1096_ SSLQA 1101_ EFRKL 1106_ QGKLK 1111_ NAHNI 1116_ INLLK 1121_ EQLVL 1126_ SSKEG 1131_ NSKLT 1136_ PELLV 1141_ HLTST 1146_ IERIN 1151_ TELVG 1156_ SPGKH 1161_ QHQEE 1166_ GNVTV 1171_ RPFPR 1176_ PQSLD 1181_ LGATF 1186_ TVDAH 1191_ QLDNQ 1196_ SQPRD 1201_ PGPQS 1206_ AFSLP 1211_ GSTQH 1216_ LRSQL 1221_ SQCKQ 1226_ RYQDL 1231_ QEKLL 1236_ LSEAT 1241_ VFAQA 1246_ NELEK 1251_ YRVML 1256_ TGESL 1261_ VKQDS 1266_ KQIQV 1271_ DLQDL 1276_ GYETC 1281_ GRSEN 1286_ EAERE 1291_ ETTSP 1296_ ECEEH 1301_ NSLKE 1306_ MVLME 1311_ GLCSE 1316_ QGRRG 1321_ STLAS 1326_ SSERK 1331_ PLENQ 1336_ LGKQE 1341_ EFRVY 1346_ GKSEN 1351_ ILVLR 1356_ KDIKD 1361_ LKAQL 1366_ QNANK 1371_ VIQNL 1376_ KSRVR 1381_ SLSVT 1386_ SDYSS 1391_ SLERP 1396_ RKLRA 1401_ VGTLE 1406_ GSSPH 1411_ SVPDE 1416_ DEGWL 1421_ SDGTG 1426_ AFYSP 1431_ GLQAK 1436_ KDLES 1441_ LIQRV 1446_ SQLEA 1451_ QLPKN 1456_ GLEEK 1461_ LAEEL 1466_ RSASW 1471_ PGKYD 1476_ SLIQD 1481_ QAREL 1486_ SYLRQ 1491_ KIREG 1496_ RGICY 1501_ LITRH 1506_ AKDTV 1511_ KSFED 1516_ LLRSN 1521_ DIDYY 1526_ LGQSF 1531_ REQLA 1536_ QGSQL 1541_ TERLT 1546_ SKLST 1551_ KDHKS 1556_ EKDQA 1561_ GLEPL 1566_ ALRLS 1571_ RELQE 1576_ KEKVI 1581_ EVLQA 1586_ KLDAR 1591_ SLTPS 1596_ SSHAL 1601_ SDSHR 1606_ SPSST 1611_ SFLSD 1616_ ELEAC 1621_ SDMDI 1626_ VSEYT 1631_ HYEEK 1636_ KASPS 1641_ HSDSI 1646_ HHSSH 1651_ SAVLS 1656_ SKPSS 1661_ TSASQ 1666_ GAKAE 1671_ SNSNP 1676_ ISLPT 1681_ PQNTP 1686_ KEANQ 1691_ AHSGF 1696_ HFHSI 1701_ PKLAS 1706_ LPQAP 1711_ LPSAP 1716_ SSFLP 1721_ FSPTG 1726_ PLLLG 1731_ CCETP 1736_ VVSLA 1741_ EAQQE 1746_ LQMLQ 1751_ KQLGE 1756_ SASTV 1761_ PPAST 1766_ ATLLS 1771_ NDLEA 1776_ DSSYY 1781_ LNSAQ 1786_ PHSPP 1791_ RGTIE 1796_ LGRIL 1801_ EPGYL 1806_ GSSGK 1811_ WDVMR 1816_ PQKGS 1821_ VSGDL 1826_ SSGSS 1831_ VYQLN 1836_ SKPTG 1841_ ADLLE 1846_ EHLGE 1851_ IRNLR 1856_ QRLEE 1861_ SICIN 1866_ DRLRE 1871_ QLEHR 1876_ LTSTA 1881_ RGRGS 1886_ TSNFY 1891_ SQGLE 1896_ SIPQL 1901_ CNENR 1906_ VLRED 1911_ NRRLQ 1916_ AQLSH 1921_ VSREH 1926_ SQETE 1931_ SLREA 1936_ LLSSR 1941_ SHLQE 1946_ LEKEL 1951_ EHQKV 1956_ ERQQL 1961_ LEDLR 1966_ EKQQE 1971_ VLHFR 1976_ EERLS 1981_ LQEND 1986_ SRLQH 1991_ KLVLL 1996_ QQQCE 2001_ EKQQL 2006_ FESLQ 2011_ SELQI 2016_ YEALY 2021_ GNSKK 2026_ GLKAY 2031_ SLDAC 2036_ HQIPL 2041_ SSDLS 2046_ HLVAE 2051_ VRALR 2056_ GQLEQ 2061_ SIQGN 2066_ NCLRL 2071_ QLQQQ 2076_ LESGA 2081_ GKASL 2086_ SPSSI 2091_ NQNFP 2096_ ASTDP 2101_ GNKQL 2106_ LLQDS 2111_ AVSPP 2116_ VRDVG 2121_ MNSPA 2126_ LVFPS 2131_ SASST 2136_ PGSET 2141_ PIINR 2146_ ANGLG 2151_ LDTSP 2156_ VMKTP 2161_ PKLEG 2166_ DATDG 2171_ SFANK 2176_ HGRHV 2181_ IGHID 2186_ DYSAL 2191_ RQQIA 2196_ EGKLL 2201_ VKKIV 2206_ SLVRS 2211_ ACSFP 2216_ GLEAQ 2221_ GTEVL 2226_ GSKGI 2231_ HELRS 2236_ STSAL 2241_ HHALE 2246_ ESASL 2251_ LTMFW 2256_ RAALP 2261_ STHIP 2266_ VLPGK 2271_ VGEST 2276_ ERELL 2281_ ELRTK 2286_ VSKQE 2291_ RLLQS 2296_ TTEHL 2301_ KNANQ 2306_ QKESM 2311_ EQFIV 2316_ SQLTR 2321_ THDVL 2326_ KKART 2331_ NLEVK 2336_ SLRAL 2341_PCTPA

Protein annotations

Protein functions:

1: Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity)

2: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697)