Cytosolic carboxypeptidase 6 (EC 3.4.17.24) (ATP/GTP-binding protein-like 4) (Protein deglutamylase CCP6)
1_MAEGS 6_ QSAPE 11_ AGNDM 16_ GNDDA 21_ IGGNV 26_ SKYIV 31_ LPTGY 36_ CGQPK 41_ KGHLI 46_ FDACF 51_ ESGNL 56_ GRVDQ 61_ VSEFE 66_ YDLFI 71_ RPDTC 76_ NPRFR 81_ VWFNF 86_ TVENV 91_ KESQR 96_ VIFNI 101_ VNFSK 106_ TKSLY 111_ RDGMA 116_ PMVKS 121_ TSRPK 126_ WQRLP 131_ PKNVY 136_ YYRCP 141_ DHRKN 146_ YVMSF 151_ AFCFD 156_ REEDI 161_ YQFAY 166_ CYPYT 171_ YTRFQ 176_ HYLDS 181_ LQKRN 186_ MDYFF 191_ REQLG 196_ QSVQQ 201_ RKLDL 206_ LTITS 211_ PDNLR 216_ EGAEQ 221_ KVVFI 226_ TGRVH 231_ PGETP 236_ SSFVC 241_ QGIID 246_ FLVSQ 251_ HPIAC 256_ VLREY 261_ LVFKI 266_ APMLN 271_ PDGVY 276_ LGNYR 281_ CSLMG 286_ FDLNR 291_ HWLDP 296_ SPWVH 301_ PTLHG 306_ VKQLI 311_ VQMYN 316_ DPKTS 321_ LEFYI 326_ DIHAH 331_ STMMN 336_ GFMYG 341_ NIFED 346_ EERFQ 351_ RQAIF 356_ PKLLC 361_ QNAED 366_ FSYSS 371_ TSFNR 376_ DAVKA 381_ GTGRR 386_ FLGGL 391_ LDHTS 396_ YCYTL 401_ EVSFY 406_ SYIIS 411_ GTTAA 416_ VPYTE 421_ EAYMK 426_ LGRNV 431_ ARTFL 436_ DYYRL 441_ NPVVE 446_ KVAIP 451_ MPRLR 456_ NKEIE 461_ VQRRK 466_ EKSPP 471_ YKHPL 476_ LRGPA 481_ SNYPN 486_ SKGDK 491_ KSSVN 496_HKDPS
1: Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (By similarity). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216)