Succinate dehydrogenase assembly factor 4, mitochondrial (SDH assembly factor 4) (SDHAF4)
1_MTPSR 6_ LPWLL 11_ SWVSA 16_ TAWRA 21_ ARSPL 26_ LCHSL 31_ RKTSS 36_ SQGGK 41_ SELVK 46_ QSLKK 51_ PKLPE 56_ GRFDA 61_ PEDSH 66_ LEKEP 71_ LEKFP 76_ DDVNP 81_ VTKEK 86_ GGPRG 91_ PEPTR 96_ YGDWE 101_RKGRC
1: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity)