OTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7)
1_MQLYS 6_ SVCTH 11_ YPAGA 16_ PGPTA 21_ AAPAP 26_ PAAAT 31_ PFKVS 36_ LQPPG 41_ AAGAA 46_ PEPET 51_ GECQP 56_ AAAAE 61_ HREAA 66_ AVPAA 71_ KMPAF 76_ SSCFE 81_ VVSGA 86_ AAPAS 91_ AAAGP 96_ PGASC 101_ KPPLP 106_ PHYTS 111_ TAQIT 116_ VRALG 121_ ADRLL 126_ LHGPD 131_ PVPGA 136_ AGSAA 141_ APRGR 146_ CLLLA 151_ PAPAA 156_ PVPPR 161_ RGSSA 166_ WLLEE 171_ LLRPD 176_ CPEPA 181_ GLDAT 186_ REGPD 191_ RNFRL 196_ SEHRQ 201_ ALAAA 206_ KHRGP 211_ AATPG 216_ SPDPG 221_ PGPWG 226_ EEHLA 231_ ERGPR 236_ GWERG 241_ GDRCD 246_ APGGD 251_ AARRP 256_ DPEAE 261_ APPAG 266_ SIEAA 271_ PSSAA 276_ EPVIV 281_ SRSDP 286_ RDEKL 291_ ALYLA 296_ EVEKQ 301_ DKYLR 306_ QRNKY 311_ RFHII 316_ PDGNC 321_ LYRAV 326_ SKTVY 331_ GDQSL 336_ HRELR 341_ EQTVH 346_ YIADH 351_ LDHFS 356_ PLIEG 361_ DVGEF 366_ IIAAA 371_ QDGAW 376_ AGYPE 381_ LLAMG 386_ QMLNV 391_ NIHLT 396_ TGGRL 401_ ESPTV 406_ STMIH 411_ YLGPE 416_ DSLRP 421_ SIWLS 426_ WLSNG 431_ HYDAV 436_ FDHSY 441_ PNPEY 446_ DNWCK 451_ QTQVQ 456_ RKRDE 461_ ELAKS 466_ MAISL 471_ SKMYI 476_EQNAC
1: Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin (PubMed:23827681). Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:36445135). The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598 (PubMed:36445135). OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation (PubMed:36445135)