Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1)
1_MAAEE 6_ ADVDI 11_ EGDVV 16_ AAAGA 21_ QPGSG 26_ ENTAS 31_ VLQKD 36_ HYLDS 41_ SWRTE 46_ NGLIP 51_ WTLDN 56_ TISEE 61_ NRAVI 66_ EKMLL 71_ EEEYY 76_ LSKKS 81_ QPEKV 86_ WLDQK 91_ EDDKK 96_ YMKSL 101_ QKTAK 106_ IMVHS 111_ PTKPA 116_ SYSVK 121_ WTIEE 126_ KELFE 131_ QGLAK 136_ FGRRW 141_ TKISK 146_ LIGSR 151_ TVLQV 156_ KSYAR 161_ QYFKN 166_ KVKCG 171_ LDKET 176_ PNQKT 181_ GHNLQ 186_ VKNED 191_ KGTKA 196_ WTPSC 201_ LRGRA 206_ DPNLN 211_ AVKIE 216_ KLSDD 221_ EEVDI 226_ TDEVD 231_ ELSSQ 236_ TPQKN 241_ SSSDL 246_ LLDFP 251_ NSKMH 256_ ETNQG 261_ EFITS 266_ DSQEA 271_ LFSKS 276_ SRGCL 281_ QNEKQ 286_ DETLS 291_ SSEIT 296_ LWTEK 301_ QSNGD 306_ KKSIE 311_ LNDQK 316_ FNELI 321_ KNCNK 326_ HDGRG 331_ IIVDA 336_ RQLPS 341_ PEPCE 346_ IQKNL 351_ NDNEM 356_ LFHSC 361_ QMVEE 366_ SHEEE 371_ ELKPP 376_ EQEIE 381_ IDRNI 386_ IQEEE 391_ KQAIP 396_ EFFEG 401_ RQAKT 406_ PERYL 411_ KIRNY 416_ ILDQW 421_ EICKP 426_ KYLNK 431_ TSVRP 436_ GLKNC 441_ GDVNC 446_ IGRIH 451_ TYLEL 456_ IGAIN 461_ FGCEQ 466_ AVYNR 471_ PQTVD 476_ KVRIR 481_ DRKDA 486_ VEAYQ 491_ LAQRL 496_ QSMRT 501_ RRRRV 506_ RDPWG 511_ NWCDA 516_ KDLEG 521_ QTFEH 526_ LSAEE 531_ LAKRR 536_ EEEKG 541_ RPVKS 546_ LKVPR 551_ PTKSS 556_ FDPFQ 561_ LIPCN 566_ FFSEE 571_ KQEPF 576_ QVKVA 581_ SEALL 586_ IMDLH 591_ AHVSM 596_ AEVIG 601_ LLGGR 606_ YSEVD 611_ KVVEV 616_ CAAEP 621_ CNSLS 626_ TGLQC 631_ EMDPV 636_ SQTQA 641_ SETLA 646_ VRGFS 651_ VIGWY 656_ HSHPA 661_ FDPNP 666_ SLRDI 671_ DTQAK 676_ YQSYF 681_ SRGGA 686_ KFIGM 691_ IVSPY 696_ NRNNP 701_ LPYSQ 706_ ITCLV 711_ ISEEI 716_ SPDGS 721_ YRLPY 726_ KFEVQ 731_ QMLEE 736_ PQWGL 741_ VFEKT 746_ RWIIE 751_ KYRLS 756_ HSSVP 761_ MDKIF 766_ RRDSD 771_ LTCLQ 776_ KLLEC 781_ MRKTL 786_ SKVTN 791_ CFMAE 796_ EFLTE 801_ IENLF 806_ LSNYK 811_ SNQEN 816_ GVTEE 821_NCTKE
1: Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232)