Ubiquitin thioesterase OTU1 (EC 3.4.19.12) (DUBA-8) (HIV-1-induced protease 7) (HIN-7) (HsHIN7) (OTU domain-containing protein 2)
1_MFGPA 6_ KGRHF 11_ GVHPA 16_ PGFPG 21_ GVSQQ 26_ AAGTK 31_ AGPAG 36_ AWPVG 41_ SRTDT 46_ MWRLR 51_ CKAKD 56_ GTHVL 61_ QGLSS 66_ RTRVR 71_ ELQGQ 76_ IAAIT 81_ GIAPG 86_ GQRIL 91_ VGYPP 96_ ECLDL 101_ SNGDT 106_ ILEDL 111_ PIQSG 116_ DMLII 121_ EEDQT 126_ RPRSS 131_ PAFTK 136_ RGASS 141_ YVRET 146_ LPVLT 151_ RTVVP 156_ ADNSC 161_ LFTSV 166_ YYVVE 171_ GGVLN 176_ PACAP 181_ EMRRL 186_ IAQIV 191_ ASDPD 196_ FYSEA 201_ ILGKT 206_ NQEYC 211_ DWIKR 216_ DDTWG 221_ GAIEI 226_ SILSK 231_ FYQCE 236_ ICVVD 241_ TQTVR 246_ IDRFG 251_ EDAGY 256_ TKRVL 261_ LIYDG 266_ IHYDP 271_ LQRNF 276_ PDPDT 281_ PPLTI 286_ FSSND 291_ DIVLV 296_ QALEL 301_ ADEAR 306_ RRRQF 311_ TDVNR 316_ FTLRC 321_ MVCQK 326_ GLTGQ 331_ AEARE 336_ HAKET 341_GHTNF
1: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622)