N-terminal Xaa-Pro-Lys N-methyltransferase 2 (EC 2.1.1.299) (Alpha N-terminal protein methyltransferase 1B) (Methyltransferase-like protein 11B) (X-Pro-Lys N-terminal protein methyltransferase 1B) (NTM1B)
1_MAHRG 6_ AHFAF 11_ RSRWQ 16_ KTDDE 21_ LCRHS 26_ MSFIL 31_ HKAIR 36_ NDFFQ 41_ SYLYL 46_ LEKIP 51_ LVKLY 56_ ALTSQ 61_ VINGE 66_ MQFYA 71_ RAKLF 76_ YQEVP 81_ ATEEG 86_ MMGNF 91_ IELSS 96_ PDIQA 101_ SQKFL 106_ RKFVG 111_ GPGRA 116_ GTDCA 121_ LDCGS 126_ GIGRV 131_ SKHVL 136_ LPVFN 141_ SVELV 146_ DMMES 151_ FLLEA 156_ QNYLQ 161_ VKGDK 166_ VESYH 171_ CYSLQ 176_ EFTPP 181_ FRRYD 186_ VIWIQ 191_ WVSGH 196_ LTDKD 201_ LLAFL 206_ SRCRD 211_ GLKEN 216_ GIIIL 221_ KDNVA 226_ REGCI 231_ LDLSD 236_ SSVTR 241_ DMDIL 246_ RSLIR 251_ KSGLV 256_ VLGQE 261_ KQDGF 266_ PEQCI 271_ PVWMF 276_ALHSD
1: Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif (PubMed:24090352, PubMed:30417120). Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro) (PubMed:30417120). May activate NTMT1 by priming its substrates for trimethylation (PubMed:24090352)