Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 4) (HACD4) (Protein-tyrosine phosphatase-like A domain-containing protein 2)
1_MGPLA 6_ LPAWL 11_ QPRYR 16_ KNAYL 21_ FIYYL 26_ IQFCG 31_ HSWIF 36_ TNMTV 41_ RFFSF 46_ GKDSM 51_ VDTFY 56_ AIGLV 61_ MRLCQ 66_ SVSLL 71_ ELLHI 76_ YVGIE 81_ SNHLL 86_ PRFLQ 91_ LTERI 96_ IILFV 101_ VITSQ 106_ EEVQE 111_ KYVVC 116_ VLFVF 121_ WNLLD 126_ MVRYT 131_ YSMLS 136_ VIGIS 141_ YAVLT 146_ WLSQT 151_ LWMPI 156_ YPLCV 161_ LAEAF 166_ AIYQS 171_ LPYFE 176_ SFGTY 181_ STKLP 186_ FDLSI 191_ YFPYV 196_ LKIYL 201_ MMLFI 206_ GMYFT 211_ YSHLY 216_ SERRD 221_ ILGIF 226_PIKKK
1: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators