Interleukin-23 receptor (IL-23 receptor) (IL-23R)
1_MNQVT 6_ IQWDA 11_ VIALY 16_ ILFSW 21_ CHGGI 26_ TNINC 31_ SGHIW 36_ VEPAT 41_ IFKMG 46_ MNISI 51_ YCQAA 56_ IKNCQ 61_ PRKLH 66_ FYKNG 71_ IKERF 76_ QITRI 81_ NKTTA 86_ RLWYK 91_ NFLEP 96_ HASMY 101_ CTAEC 106_ PKHFQ 111_ ETLIC 116_ GKDIS 121_ SGYPP 126_ DIPDE 131_ VTCVI 136_ YEYSG 141_ NMTCT 146_ WNAGK 151_ LTYID 156_ TKYVV 161_ HVKSL 166_ ETEEE 171_ QQYLT 176_ SSYIN 181_ ISTDS 186_ LQGGK 191_ KYLVW 196_ VQAAN 201_ ALGME 206_ ESKQL 211_ QIHLD 216_ DIVIP 221_ SAAVI 226_ SRAET 231_ INATV 236_ PKTII 241_ YWDSQ 246_ TTIEK 251_ VSCEM 256_ RYKAT 261_ TNQTW 266_ NVKEF 271_ DTNFT 276_ YVQQS 281_ EFYLE 286_ PNIKY 291_ VFQVR 296_ CQETG 301_ KRYWQ 306_ PWSSL 311_ FFHKT 316_ PETVP 321_ QVTSK 326_ AFQHD 331_ TWNSG 336_ LTVAS 341_ ISTGH 346_ LTSDN 351_ RGDIG 356_ LLLGM 361_ IVFAV 366_ MLSIL 371_ SLIGI 376_ FNRSF 381_ RTGIK 386_ RRILL 391_ LIPKW 396_ LYEDI 401_ PNMKN 406_ SNVVK 411_ MLQEN 416_ SELMN 421_ NNSSE 426_ QVLYV 431_ DPMIT 436_ EIKEI 441_ FIPEH 446_ KPTDY 451_ KKENT 456_ GPLET 461_ RDYPQ 466_ NSLFD 471_ NTTVV 476_ YIPDL 481_ NTGYK 486_ PQISN 491_ FLPEG 496_ SHLSN 501_ NNEIT 506_ SLTLK 511_ PPVDS 516_ LDSGN 521_ NPRLQ 526_ KHPNF 531_ AFSVS 536_ SVNSL 541_ SNTIF 546_ LGELS 551_ LILNQ 556_ GECSS 561_ PDIQN 566_ SVEEE 571_ TTMLL 576_ ENDSP 581_ SETIP 586_ EQTLL 591_ PDEFV 596_ SCLGI 601_ VNEEL 606_ PSINT 611_ YFPQN 616_ ILESH 621_FNRIS
1: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis