Terminal nucleotidyltransferase 5C (EC 2.7.7.19) (Non-canonical poly(A) polymerase FAM46C)
1_MAEES 6_ SCTRD 11_ CMSFS 16_ VLNWD 21_ QVSRL 26_ HEVLT 31_ EVVPI 36_ HGRGN 41_ FPTLE 46_ ITLKD 51_ IVQTV 56_ RSRLE 61_ EAGIK 66_ VHDVR 71_ LNGSA 76_ AGHVL 81_ VKDNG 86_ LGCKD 91_ LDLIF 96_ HVALP 101_ TEAEF 106_ QLVRD 111_ VVLCS 116_ LLNFL 121_ PEGVN 126_ KLKIS 131_ PVTLK 136_ EAYVQ 141_ KLVKV 146_ CTDTD 151_ RWSLI 156_ SLSNK 161_ NGKNV 166_ ELKFV 171_ DSIRR 176_ QFEFS 181_ VDSFQ 186_ IILDS 191_ LLFFY 196_ DCSNN 201_ PISEH 206_ FHPTV 211_ IGESM 216_ YGDFE 221_ EAFDH 226_ LQNRL 231_ IATKN 236_ PEEIR 241_ GGGLL 246_ KYSNL 251_ LVRDF 256_ RPTDQ 261_ EEIKT 266_ LERYM 271_ CSRFF 276_ IDFPD 281_ ILEQQ 286_ RKLET 291_ YLQNH 296_ FAEEE 301_ RSKYD 306_ YLMIL 311_ RRVVN 316_ ESTVC 321_ LMGHE 326_ RRQTL 331_ NLISL 336_ LALRV 341_ LAEQN 346_ IIPSA 351_ TNVTC 356_ YYQPA 361_ PYVSD 366_ GNFSN 371_ YYVAH 376_ PPVTY 381_ SQPYP 386_TWLPC
1: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression (PubMed:28931820, PubMed:32009146, PubMed:34048638). Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich (PubMed:34048638). Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein (PubMed:28931820)
2: (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon