KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Sam68-like mammalian protein 1) (SLM-1) (hSLM-1)
1_MEEEK 6_ YLPEL 11_ MAEKD 16_ SLDPS 21_ FVHAS 26_ RLLAE 31_ EIEKF 36_ QGSDG 41_ KKEDE 46_ EKKYL 51_ DVISN 56_ KNIKL 61_ SERVL 66_ IPVKQ 71_ YPKFN 76_ FVGKL 81_ LGPRG 86_ NSLKR 91_ LQEET 96_ GAKMS 101_ ILGKG 106_ SMRDK 111_ AKEEE 116_ LRKSG 121_ EAKYA 126_ HLSDE 131_ LHVLI 136_ EVFAP 141_ PGEAY 146_ SRMSH 151_ ALEEI 156_ KKFLV 161_ PDYND 166_ EIRQE 171_ QLREL 176_ SYLNG 181_ SEDSG 186_ RGRGI 191_ RGRGI 196_ RIAPT 201_ APSRG 206_ RGGAI 211_ PPPPP 216_ PGRGV 221_ LTPRG 226_ STVTR 231_ GALPV 236_ PPVAR 241_ GVPTP 246_ RARGA 251_ PTVPG 256_ YRAPP 261_ PPAHE 266_ AYEEY 271_ GYDDG 276_ YGGEY 281_ DDQTY 286_ ETYDN 291_ SYATQ 296_ TQSVP 301_ EYYDY 306_ GHGVS 311_ EDAYD 316_ SYAPE 321_ EWATT 326_ RSSLK 331_ APPQR 336_ SARGG 341_YREHP
1: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis