Lysophospholipase-like protein 1 (EC 3.1.2.22)
1_MAAAS 6_ GSVLQ 11_ RCIVS 16_ PAGRH 21_ SASLI 26_ FLHGS 31_ GDSGQ 36_ GLRMW 41_ IKQVL 46_ NQDLT 51_ FQHIK 56_ IIYPT 61_ APPRS 66_ YTPMK 71_ GGISN 76_ VWFDR 81_ FKITN 86_ DCPEH 91_ LESID 96_ VMCQV 101_ LTDLI 106_ DEEVK 111_ SGIKK 116_ NRILI 121_ GGFSM 126_ GGCMA 131_ IHLAY 136_ RNHQD 141_ VAGVF 146_ ALSSF 151_ LNKAS 156_ AVYQA 161_ LQKSN 166_ GVLPE 171_ LFQCH 176_ GTADE 181_ LVLHS 186_ WAEET 191_ NSMLK 196_ SLGVT 201_ TKFHS 206_ FPNVY 211_ HELSK 216_ TELDI 221_ LKLWI 226_ LTKLP 231_GEMEK
1: Palmitoyl thioesterase that catalyzes depalmitoylation of CGAS and KCNMA1 (PubMed:22052940, PubMed:22399288, PubMed:37802025). Acts as a regulator of innate immunity by mediating depalmitoylation of CGAS, thereby preventing CGAS homodimerization and cyclic GMP-AMP synthase activity (PubMed:37802025). Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (PubMed:22052940)