Lipase member N (EC 3.1.1.-) (Lipase-like abhydrolase domain-containing protein 4)
1_MMWLL 6_ LTTTC 11_ LICGT 16_ LNAGG 21_ FLDLE 26_ NEVNP 31_ EVWMN 36_ TSEII 41_ IYNGY 46_ PSEEY 51_ EVTTE 56_ DGYIL 61_ LVNRI 66_ PYGRT 71_ HARST 76_ GPRPV 81_ VYMQH 86_ ALFAD 91_ NAYWL 96_ ENYAN 101_ GSLGF 106_ LLADA 111_ GYDVW 116_ MGNSR 121_ GNTWS 126_ RRHKT 131_ LSETD 136_ EKFWA 141_ FSFDE 146_ MAKYD 151_ LPGVI 156_ DFIVN 161_ KTGQE 166_ KLYFI 171_ GHSLG 176_ TTIGF 181_ VAFST 186_ MPELA 191_ QRIKM 196_ NFALG 201_ PTISF 206_ KYPTG 211_ IFTRF 216_ FLLPN 221_ SIIKA 226_ VFGTK 231_ GFFLE 236_ DKKTK 241_ IASTK 246_ ICNNK 251_ ILWLI 256_ CSEFM 261_ SLWAG 266_ SNKKN 271_ MNQSR 276_ MDVYM 281_ SHAPT 286_ GSSVH 291_ NILHI 296_ KQLYH 301_ SDEFR 306_ AYDWG 311_ NDADN 316_ MKHYN 321_ QSHPP 326_ IYDLT 331_ AMKVP 336_ TAIWA 341_ GGHDV 346_ LVTPQ 351_ DVARI 356_ LPQIK 361_ SLHYF 366_ KLLPD 371_ WNHFD 376_ FVWGL 381_ DAPQR 386_ MYSEI 391_IALMK
1: Plays a highly specific role in the last step of keratinocyte differentiation. Contains two distinct domains: the alpha/beta hydrolase fold and the abhydrolase-associated lipase region, also features the consensus sequence of the active site of a genuine lipase. May have an essential function in lipid metabolism of the most differentiated epidermal layers