Immediate early response gene 5 protein
1_MEFKL 6_ EAHRI 11_ VSISL 16_ GKIYN 21_ SRVQR 26_ GGIKL 31_ HKNLL 36_ VSLVL 41_ RSARQ 46_ VYLSD 51_ PCPGL 56_ YLAGP 61_ AGTPA 66_ PPPQQ 71_ QPGEP 76_ AAGPP 81_ AGWGE 86_ PPPPA 91_ ARASW 96_ PETEP 101_ QPERS 106_ SVSDA 111_ PRVGD 116_ EVPVA 121_ TVTGV 126_ GDVFQ 131_ GGEAD 136_ ATEAA 141_ WSRVE 146_ GPRQA 151_ AAREA 156_ EGTAG 161_ GWGVF 166_ PEVSR 171_ AARRP 176_ CGCPL 181_ GGEDP 186_ PGTPA 191_ ATPRA 196_ ACCCA 201_ PQPAE 206_ DEPPA 211_ PPAVC 216_ PRKRC 221_ AAGVG 226_ GGPAG 231_ CPAPG 236_ STPLK 241_ KPRRN 246_ LEQPP 251_ SGGED 256_ DDAEE 261_ METGN 266_ VANLI 271_ SIFGS 276_ SFSGL 281_ LRKSP 286_ GGGRE 291_ EEEGE 296_ ESGPE 301_ AAEPG 306_ QICCD 311_ KPVLR 316_ DMNPW 321_STAIV
1: Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193)