Renalase (EC 1.6.3.5) (Monoamine oxidase-C) (MAO-C)
1_MAQVL 6_ IVGAG 11_ MTGSL 16_ CAALL 21_ RRQTS 26_ GPLYL 31_ AVWDK 36_ AEDSG 41_ GRMTT 46_ ACSPH 51_ NPQCT 56_ ADLGA 61_ QYITC 66_ TPHYA 71_ KKHQR 76_ FYDEL 81_ LAYGV 86_ LRPLS 91_ SPIEG 96_ MVMKE 101_ GDCNF 106_ VAPQG 111_ ISSII 116_ KHYLK 121_ ESGAE 126_ VYFRH 131_ RVTQI 136_ NLRDD 141_ KWEVS 146_ KQTGS 151_ PEQFD 156_ LIVLT 161_ MPVPE 166_ ILQLQ 171_ GDITT 176_ LISEC 181_ QRQQL 186_ EAVSY 191_ SSRYA 196_ LGLFY 201_ EAGTK 206_ IDVPW 211_ AGQYI 216_ TSNPC 221_ IRFVS 226_ IDNKK 231_ RNIES 236_ SEIGP 241_ SLVIH 246_ TTVPF 251_ GVTYL 256_ EHSIE 261_ DVQEL 266_ VFQQL 271_ ENILP 276_ GLPQP 281_ IATKC 286_ QKWRH 291_ SQVTN 296_ AAANC 301_ PGQMT 306_ LHHKP 311_ FLACG 316_ GDGFT 321_ QSNFD 326_ GCITS 331_ ALCVL 336_EALKN
1: Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis