Ras-related GTP-binding protein B (Rag B) (RagB) (EC 3.6.5.-)
1_MEESD 6_ SEKTT 11_ EKENL 16_ GPRMD 21_ PPLGE 26_ PEGSL 31_ GWVLP 36_ NTAMK 41_ KKVLL 46_ MGKSG 51_ SGKTS 56_ MRSII 61_ FANYI 66_ ARDTR 71_ RLGAT 76_ ILDRI 81_ HSLQI 86_ NSSLS 91_ TYSLV 96_ DSVGN 101_ TKTFD 106_ VEHSH 111_ VRFLG 116_ NLVLN 121_ LWDCG 126_ GQDTF 131_ MENYF 136_ TSQRD 141_ NIFRN 146_ VEVLI 151_ YVFDV 156_ ESREL 161_ EKDMH 166_ YYQSC 171_ LEAIL 176_ QNSPD 181_ AKIFC 186_ LVHKM 191_ DLVQE 196_ DQRDL 201_ IFKER 206_ EEDLR 211_ RLSRP 216_ LECSC 221_ FRTSI 226_ WDETL 231_ YKAWS 236_ SIVYQ 241_ LIPNV 246_ QQLEM 251_ NLRNF 256_ AEIIE 261_ ADEVL 266_ LFERA 271_ TFLVI 276_ SHYQC 281_ KEQRD 286_ AHRFE 291_ KISNI 296_ IKQFK 301_ LSCSK 306_ LAASF 311_ QSMEV 316_ RNSNF 321_ AAFID 326_ IFTSN 331_ TYVMV 336_ VMSDP 341_ SIPSA 346_ ATLIN 351_ IRNAR 356_ KHFEK 361_ LERVD 366_GPKQC
1: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:18497260, PubMed:20381137, PubMed:23723238, PubMed:24095279). Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagB/RRAGB is in its active form when GTP-bound RagB/RRAGB forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagB/RRAGB heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) (PubMed:18497260, PubMed:20381137, PubMed:23723238, PubMed:24095279). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:18497260, PubMed:20381137, PubMed:23723238). Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008)