ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219)
1_MAQTV 6_ QNVTL 11_ SLTLP 16_ ITCHI 21_ CLGKV 26_ RQPVI 31_ CINNH 36_ VFCSI 41_ CIDLW 46_ LKNNS 51_ QCPAC 56_ RVPIT 61_ PENPC 66_ KEIIG 71_ GTSES 76_ EPMLS 81_ HTVRK 86_ HLRKT 91_ RLELL 96_ HKEYE 101_ DEIDC 106_ LQKEV 111_ EELKS 116_ KNLSL 121_ ESQIK 126_ TILDP 131_ LTLVQ 136_ GNQNE 141_ DKHLV 146_ TDNPS 151_ KINPE 156_ TVAEW 161_ KKKLR 166_ TANEI 171_ YEKVK 176_ DDVDK 181_ LKEAN 186_ KKLKL 191_ ENGGL 196_ VRENL 201_ RLKAE 206_ VDNRS 211_ PQKFG 216_ RFAVA 221_ ALQSK 226_ VEQYE 231_ RETNR 236_ LKKAL 241_ ERSDK 246_ YIEEL 251_ ESQVA 256_ QLKNS 261_ SEEKE 266_ AMNSI 271_ CQTAL 276_ SADGK 281_ GSKGS 286_ EEDVV 291_ SKNQG 296_ DSARK 301_ QPGSS 306_ TSSSS 311_ HLAKP 316_ SSSRL 321_ CDTSS 326_ ARQES 331_ TSKAD 336_ LNCSK 341_ NKDLY 346_ QEQVE 351_ VMLDV 356_ TDTSM 361_ DTYLE 366_ REWGN 371_ KPSDC 376_ VPYKD 381_ EELYD 386_ LPAPC 391_ TPLSL 396_ SCLQL 401_ STPEN 406_ RESSV 411_ VQAGG 416_ SKKHS 421_ NHLRK 426_ LVFDD 431_ FCDSS 436_ NVSNK 441_ DSSED 446_ DISRS 451_ ENEKK 456_ SECFS 461_ SPKTG 466_ FWDCC 471_ STSYA 476_ QNLDF 481_ ESSEG 486_ NTIAN 491_ SVGEI 496_ SSKLS 501_ EKSGL 506_ CLSKR 511_ LNSIR 516_ SFEMN 521_ RTRTS 526_ SEASM 531_ DAAYL 536_ DKISE 541_ LDSMM 546_ SESDN 551_ SKSPC 556_ NNGFK 561_ SLDLD 566_ GLSKS 571_ SQGSE 576_ FLEEP 581_ DKLEE 586_ KTELN 591_ LSKGS 596_ LTNDQ 601_ LENGS 606_ EWKPT 611_ SFFLL 616_ SPSDQ 621_ EMNED 626_ FSLHS 631_ SSCPV 636_ TNEIK 641_ PPSCL 646_ FQTEF 651_ SQGIL 656_ LSSSH 661_ RLFED 666_ QRFGS 671_ SLFKM 676_ SSEMH 681_ SLHNH 686_ LQSPW 691_ STSFV 696_ PEKRN 701_ KNVNQ 706_ STKRK 711_ IQSSL 716_ SSASP 721_SKATK
1: E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578)