Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20)
1_MAPWT 6_ LWRCC 11_ QRVVG 16_ WVPVL 21_ FITFV 26_ VVWSY 31_ YAYVV 36_ ELCVF 41_ TIFGN 46_ EENGK 51_ TVVYL 56_ VAFHL 61_ FFVMF 66_ VWSYW 71_ MTIFT 76_ SPASP 81_ SKEFY 86_ LSNSE 91_ KERYE 96_ KEFSQ 101_ ERQQE 106_ ILRRA 111_ ARALP 116_ IYTTS 121_ ASKTI 126_ RYCEK 131_ CQLIK 136_ PDRAH 141_ HCSAC 146_ DSCIL 151_ KMDHH 156_ CPWVN 161_ NCVGF 166_ SNYKF 171_ FLLFL 176_ LYSLL 181_ YCLFV 186_ AATVL 191_ EYFIK 196_ FWTNE 201_ LTDTR 206_ AKFHV 211_ LFLFF 216_ VSAMF 221_ FISVL 226_ SLFSY 231_ HCWLV 236_ GKNRT 241_ TIESF 246_ RAPTF 251_ SYGPD 256_ GNGFS 261_ LGCSK 266_ NWRQV 271_ FGDEK 276_ KYWLL 281_ PIFSS 286_ LGDGC 291_ SFPTR 296_ LVGMD 301_ PEQAS 306_ VTNQN 311_ EYARS 316_ SGSNQ 321_ PFPIK 326_ PLSES 331_ KNRLL 336_ DSESQ 341_ WLENG 346_ AEEGI 351_ VKSGT 356_NNHVT
1: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:27153536, PubMed:29326245, PubMed:33219126). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation (PubMed:27153536). Has a preference for acyl-CoA with C16 fatty acid chains (PubMed:29326245). Can also utilize acyl-CoA with C14 and C18 fatty acid chains (PubMed:29326245). May palmitoylate CALHM1 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics
2: (Microbial infection) Dominant palmitoyltransferase responsible for lipidation of SARS coronavirus-2/SARS-CoV-2 spike protein. Through a sequential action with ZDHHC9, rapidly and efficiently palmitoylates spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell