Terminal nucleotidyltransferase 4A (DNA polymerase sigma) (LAK-1) (Non-canonical poly(A) RNA polymerase PAPD7) (EC 2.7.7.19) (PAP-associated domain-containing protein 7) (TRAMP-like complex polyadenylate polymerase) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 5) (TUTase 5) (Topoisomerase-related function protein 4-1) (TRF4-1)
1_MQIWE 6_ TSQGV 11_ GRGGS 16_ GFASY 21_ FCLNS 26_ PALDT 31_ AAAAG 36_ AAGRG 41_ SGGLG 46_ PALPA 51_ ASPPP 56_ PGPTA 61_ PAALP 66_ PALLT 71_ ALGPA 76_ AEGAR 81_ RLHKS 86_ PSLSS 91_ SSSSS 96_ SSNAE 101_ SGTES 106_ PGCSS 111_ SSSSS 116_ ASLGR 121_ PGGGR 126_ GGAFF 131_ NFADG 136_ APSAP 141_ GTANG 146_ HPGPR 151_ GPAPA 156_ GSPSQ 161_ HQFHP 166_ GRRKR 171_ ENKAS 176_ TYGLN 181_ YLLSG 186_ SRAAA 191_ LSGGG 196_ GPGAQ 201_ APRPG 206_ TPWKS 211_ RAYSP 216_ GIQGL 221_ HEEII 226_ DFYNF 231_ MSPCP 236_ EEAAM 241_ RREVV 246_ KRIET 251_ VVKDL 256_ WPTAD 261_ VQIFG 266_ SFSTG 271_ LYLPT 276_ SDIDL 281_ VVFGK 286_ WERPP 291_ LQLLE 296_ QALRK 301_ HNVAE 306_ PCSIK 311_ VLDKA 316_ TVPII 321_ KLTDQ 326_ ETEVK 331_ VDISF 336_ NMETG 341_ VRAAE 346_ FIKNY 351_ MKKYS 356_ LLPYL 361_ ILVLK 366_ QFLLQ 371_ RDLNE 376_ VFTGG 381_ ISSYS 386_ LILMA 391_ ISFLQ 396_ LHPRI 401_ DARRA 406_ DENLG 411_ MLLVE 416_ FFELY 421_ GRNFN 426_ YLKTG 431_ IRIKE 436_ GGAYI 441_ AKEEI 446_ MKAMT 451_ SGYRP 456_ SMLCI 461_ EDPLL 466_ PGNDV 471_ GRSSY 476_ GAMQV 481_ KQVFD 486_ YAYIV 491_ LSHAV 496_ SPLAR 501_ SYPNR 506_ DAEST 511_ LGRII 516_ KVTQE 521_ VIDYR 526_ RWIKE 531_ KWGSK 536_ AHPSP 541_ GMDSR 546_ IKIKE 551_ RIATC 556_ NGEQT 561_ QNREP 566_ ESPYG 571_ QRLTL 576_ SLSSP 581_ QLLSS 586_ GSSAS 591_ SVSSL 596_ SGSDV 601_ DSDTP 606_ PCTTP 611_ SVYQF 616_ SLQAP 621_ APLMA 626_ GLPTA 631_ LPMPS 636_ GKPQP 641_ TTSRT 646_ LIMTT 651_ NNQTR 656_ FTIPP 661_ PTLGV 666_ APVPC 671_ RQAGV 676_ EGTAS 681_ LKAVH 686_ HMSSP 691_ AIPSA 696_ SPNPL 701_ SSPHL 706_ YHKQH 711_ NGMKL 716_ SMKGS 721_ HGHTQ 726_ GGGYS 731_ SVGSG 736_ GVRPP 741_ VGNRG 746_ HHQYN 751_ RTGWR 756_ RKKHT 761_ HTRDS 766_LPVSL
1: Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed:23376078)