Caspase recruitment domain-containing protein 17 (Caspase-1 inhibitor INCA) (Inhibitory caspase recruitment domain protein)
1_MADKV 6_ LKEKR 11_ KQFIR 16_ SVGEG 21_ TINGL 26_ LGELL 31_ ETRVL 36_ SQEEI 41_ EIVKC 46_ ENATV 51_ MDKAR 56_ ALLDS 61_ VIRKG 66_ APACQ 71_ ICITY 76_ ICEED 81_ SHLAG 86_ TLGLS 91_ AGPTS 96_ GNHLT 101_TQDSQ
1: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation