E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) (RING-type E3 ubiquitin transferase RNF123)
1_MASKG 6_ AGMSF 11_ SRKSY 16_ RLTSD 21_ AEKSR 26_ VTGIV 31_ QEKLL 36_ NDYLN 41_ RIFSS 46_ SEHAP 51_ PAATS 56_ RKPLN 61_ FQNLP 66_ EHLDQ 71_ LLQVD 76_ NEEEE 81_ SQGQV 86_ EGRLG 91_ PSTVV 96_ LDHTG 101_ GFEGL 106_ LLVDD 111_ DLLGV 116_ IGHSN 121_ FGTIR 126_ STTCV 131_ YKGKW 136_ LYEVL 141_ ISSQG 146_ LMQIG 151_ WCTIS 156_ CRFNQ 161_ EEGVG 166_ DTHNS 171_ YAYDG 176_ NRVRK 181_ WNVTT 186_ TNYGK 191_ AWAAG 196_ DIVSC 201_ LIDLD 206_ DGTLS 211_ FCLNG 216_ VSLGT 221_ AFENL 226_ SRGLG 231_ MAYFP 236_ AISLS 241_ FKESV 246_ AFNFG 251_ SRPLR 256_ YPVAG 261_ YRPLQ 266_ DPPSA 271_ DLVRA 276_ QRLLG 281_ CFRAV 286_ LSVEL 291_ DPVEG 296_ RLLDK 301_ ESSKW 306_ RLRGQ 311_ PTVLL 316_ TLAHI 321_ FHHFA 326_ PLLRK 331_ VYLVE 336_ AVLMS 341_ FLLGI 346_ VEKGT 351_ PTQAQ 356_ SVVHQ 361_ VLDLL 366_ WLFME 371_ DYEVQ 376_ DCLKQ 381_ LMMSL 386_ LRLYR 391_ FSPIV 396_ PDLGL 401_ QIHYL 406_ RLTIA 411_ ILRHE 416_ KSRKF 421_ LLSNV 426_ LFDVL 431_ RSVVF 436_ FYIKS 441_ PLRVE 446_ EAGLQ 451_ ELIPT 456_ TWWPH 461_ CSSRE 466_ GKEST 471_ EMKEE 476_ TAEER 481_ LRRRA 486_ YERGC 491_ QRLRK 496_ RIEVV 501_ EELQV 506_ QILKL 511_ LLDNK 516_ DDNGG 521_ EASRY 526_ IFLTK 531_ FRKFL 536_ QENAS 541_ GRGNM 546_ PMLCP 551_ PEYMV 556_ CFLHR 561_ LISAL 566_ RYYWD 571_ EYKAS 576_ NPHAS 581_ FSEEA 586_ YIPPQ 591_ VFYNG 596_ KVDYF 601_ DLQRL 606_ GGLLS 611_ HLRKT 616_ LKDDL 621_ ASKAN 626_ IVIDP 631_ LELQS 636_ TAMDD 641_ LDEDE 646_ EPAPA 651_ MAQRP 656_ MQALA 661_ VGGPL 666_ PLPRP 671_ GWLSS 676_ PTLGR 681_ ANRFL 686_ STAAV 691_ SLMTP 696_ RRPLS 701_ TSEKV 706_ KVRTL 711_ SVEQR 716_ TREDI 721_ EGSHW 726_ NEGLL 731_ LGRPP 736_ EEPEQ 741_ PLTEN 746_ SLLEV 751_ LDGAV 756_ MMYNL 761_ SVHQQ 766_ LGKMV 771_ GVSDD 776_ VNEYA 781_ MALRD 786_ TEDKL 791_ RRCPK 796_ RRKDI 801_ LAELT 806_ KSQKV 811_ FSEKL 816_ DHLSR 821_ RLAWV 826_ HATVY 831_ SQEKM 836_ LDIYW 841_ LLRVC 846_ LRTIE 851_ HGDRT 856_ GSLFA 861_ FMPEF 866_ YLSVA 871_ INSYS 876_ ALKNY 881_ FGPVH 886_ SMEEL 891_ PGYEE 896_ TLTRL 901_ AAILA 906_ KHFAD 911_ ARIVG 916_ TDIRD 921_ SLMQA 926_ LASYV 931_ CYPHS 936_ LRAVE 941_ RIPEE 946_ QRIAM 951_ VRNLL 956_ APYEQ 961_ RPWAQ 966_ TNWIL 971_ VRLWR 976_ GCGFG 981_ YRYTR 986_ LPHLL 991_ KTKLE 996_ DANLP 1001_ SLQKP 1006_ CPSTL 1011_ LQQHM 1016_ ADLLQ 1021_ QGPDV 1026_ APSFL 1031_ NSVLN 1036_ QLNWA 1041_ FSEFI 1046_ GMIQE 1051_ IQQAA 1056_ ERLER 1061_ NFVDS 1066_ RQLKV 1071_ CATCF 1076_ DLSVS 1081_ LLRVL 1086_ EMTIT 1091_ LVPEI 1096_ FLDWT 1101_ RPTSE 1106_ MLLRR 1111_ LAQLL 1116_ NQVLN 1121_ RVTAE 1126_ RNLFD 1131_ RVVTL 1136_ RLPGL 1141_ ESVDH 1146_ YPILV 1151_ AVTGI 1156_ LVQLL 1161_ VRGPA 1166_ SEREQ 1171_ ATSVL 1176_ LADPC 1181_ FQLRS 1186_ ICYLL 1191_ GQPEP 1196_ PAPGT 1201_ ALPAP 1206_ DRKRF 1211_ SLQSY 1216_ ADYIS 1221_ ADELA 1226_ QVEQM 1231_ LAHLT 1236_ SASAQ 1241_ AAAAS 1246_ LPTSE 1251_ EDLCP 1256_ ICYAH 1261_ PISAV 1266_ FQPCG 1271_ HKSCK 1276_ ACINQ 1281_ HLMNN 1286_ KDCFF 1291_ CKTTI 1296_ VSVED 1301_ WEKGA 1306_NTSTT
1: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase (PubMed:15531880, PubMed:16227581, PubMed:25860612). Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle (PubMed:15531880, PubMed:16227581). Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit (PubMed:25860612, PubMed:33168738, PubMed:34873064). Also functions as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity (PubMed:27312109). Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS (PubMed:27312109)