F-box only protein 31
1_MAVCA 6_ RLCGV 11_ GPSRG 16_ CRRRQ 21_ QRRGP 26_ AETAA 31_ ADSEP 36_ DTDPE 41_ EERIE 46_ ASAGV 51_ GGGLC 56_ AGPSP 61_ PPPRC 66_ SLLEL 71_ PPELL 76_ VEIFA 81_ SLPGT 86_ DLPSL 91_ AQVCT 96_ KFRRI 101_ LHTDT 106_ IWRRR 111_ CREEY 116_ GVCEN 121_ LRKLE 126_ ITGVS 131_ CRDVY 136_ AKLLH 141_ RYRHI 146_ LGLWQ 151_ PDIGP 156_ YGGLL 161_ NVVVD 166_ GLFII 171_ GWMYL 176_ PPHDP 181_ HVDDP 186_ MRFKP 191_ LFRIH 196_ LMERK 201_ AATVE 206_ CMYGH 211_ KGPHH 216_ GHIQI 221_ VKKDE 226_ FSTKC 231_ NQTDH 236_ HRMSG 241_ GRQEE 246_ FRTWL 251_ REEWG 256_ RTLED 261_ IFHEH 266_ MQELI 271_ LMKFI 276_ YTSQY 281_ DNCLT 286_ YRRIY 291_ LPPSR 296_ PDDLI 301_ KPGLF 306_ KGTYG 311_ SHGLE 316_ IVMLS 321_ FHGRR 326_ ARGTK 331_ ITGDP 336_ NIPAG 341_ QQTVE 346_ IDLRH 351_ RIQLP 356_ DLENQ 361_ RNFNE 366_ LSRIV 371_ LEVRE 376_ RVRQE 381_ QQEGG 386_ HEAGE 391_ GRGRQ 396_ GPRES 401_ QPSPA 406_ QPRAE 411_ APSKG 416_ PDGTP 421_ GEDGG 426_ EPGDA 431_ VAAAE 436_ QPAQC 441_ GQGQP 446_ FVLPV 451_ GVSSR 456_ NEDYP 461_ RTCRM 466_ CFYGT 471_ GLIAG 476_ HGFTS 481_ PERTP 486_ GVFIL 491_ FDEDR 496_ FGFVW 501_ LELKS 506_ FSLYS 511_ RVQAT 516_ FRNAD 521_ APSPQ 526_ AFDEM 531_LKNIQ
1: Substrate-recognition component of the SCF(FBXO31) protein ligase complex, which specifically mediates the ubiquitination of proteins amidated at their C-terminus in response to oxidative stress, leading to their degradation by the proteasome (PubMed:39880951). FBXO31 specifically recognizes and binds C-terminal peptides bearing an amide: C-terminal amidation in response to oxidative stress takes place following protein fragmentation (PubMed:39880951). The SCF(FBXO31) also plays a role in G1 arrest following DNA damage by mediating ubiquitination of phosphorylated cyclin-D1 (CCND1), promoting its degradation by the proteasome, resulting in G1 arrest (PubMed:19412162, PubMed:29279382). The SCF(FBXO31) complex is however not a major regulator of CCND1 stability during the G1/S transition (By similarity). In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated MDM2, thereby promoting p53/TP53-mediated DNA damage response (PubMed:26124108). SCF(FBXO31) complex is required for genomic integrity by catalyzing ubiquitination and degradation of cyclin-A (CCNA1 and/or CCNA2) during the G1 phase (PubMed:31413110). In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated FBXO46 and MAP2K6 (PubMed:24936062, PubMed:30171069). SCF(FBXO31) complex promotes ubiquitination and degradation of CDT1 during the G2 phase to prevent re-replication (PubMed:24828503). The SCF(FBXO31) complex also mediates ubiquitination and degradation of DUSP6, OGT and PARD6A (PubMed:23469015, PubMed:34686346, PubMed:39894887)