CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)
1_MLRRR 6_ GSPGM 11_ GVHVG 16_ AALGA 21_ LWFCL 26_ TGALE 31_ VQVPE 36_ DPVVA 41_ LVGTD 46_ ATLCC 51_ SFSPE 56_ PGFSL 61_ AQLNL 66_ IWQLT 71_ DTKQL 76_ VHSFA 81_ EGQDQ 86_ GSAYA 91_ NRTAL 96_ FPDLL 101_ AQGNA 106_ SLRLQ 111_ RVRVA 116_ DEGSF 121_ TCFVS 126_ IRDFG 131_ SAAVS 136_ LQVAA 141_ PYSKP 146_ SMTLE 151_ PNKDL 156_ RPGDT 161_ VTITC 166_ SSYQG 171_ YPEAE 176_ VFWQD 181_ GQGVP 186_ LTGNV 191_ TTSQM 196_ ANEQG 201_ LFDVH 206_ SILRV 211_ VLGAN 216_ GTYSC 221_ LVRNP 226_ VLQQD 231_ AHSSV 236_ TITPQ 241_ RSPTG 246_ AVEVQ 251_ VPEDP 256_ VVALV 261_ GTDAT 266_ LRCSF 271_ SPEPG 276_ FSLAQ 281_ LNLIW 286_ QLTDT 291_ KQLVH 296_ SFTEG 301_ RDQGS 306_ AYANR 311_ TALFP 316_ DLLAQ 321_ GNASL 326_ RLQRV 331_ RVADE 336_ GSFTC 341_ FVSIR 346_ DFGSA 351_ AVSLQ 356_ VAAPY 361_ SKPSM 366_ TLEPN 371_ KDLRP 376_ GDTVT 381_ ITCSS 386_ YRGYP 391_ EAEVF 396_ WQDGQ 401_ GVPLT 406_ GNVTT 411_ SQMAN 416_ EQGLF 421_ DVHSV 426_ LRVVL 431_ GANGT 436_ YSCLV 441_ RNPVL 446_ QQDAH 451_ GSVTI 456_ TGQPM 461_ TFPPE 466_ ALWVT 471_ VGLSV 476_ CLIAL 481_ LVALA 486_ FVCWR 491_ KIKQS 496_ CEEEN 501_ AGAED 506_ QDGEG 511_ EGSKT 516_ ALQPL 521_ KHSDS 526_KEDDG
1: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling